Chromatographic Characterization and Method Development for Determination of Levetiracetam in Saliva: Application to Correlation with Plasma Levels

Table 2

Comparison of analytical performance of the proposed method with relevant published methods.

Validation parameter	Proposed method	Guo et al., 2007; LC-MS/MS	Mecarelli et al., 2007; GC-MS
LOQ (µg/ml)	0.24	1	1.1
Linearity ()	>0.992	NA	0.998
Precision (RSD)	7.6–4.3%	8.2–5.3%	13–2%
Recovery	98.2–99.6	103–108	NA
Accuracy (% error)	4.2–1.6%	Judged by recovery	17.9–0.3%

Lowest concentration on calibration curve.