Research Article
Simultaneous Determination of 11 Compounds in Gualou Guizhi Granule and Pharmacokinetics Study by UPLC-MS/MS
Table 1
MS analysis of parameters of detected compounds and internal standards (ISs).
| | Analyte | RT (min) | [M ā H]ā (m/z) | MSn (m/z) |
| | Paeoniflorin sulfonate (12) | 2.18 | 543.11 | 121.02 | | Albiflorin (2) | 3.67 | 525.16 | 121.02 | | Paeoniflorin (1) | 3.90 | 525.16 | 121.02 | | Liquirtin apioside (5) | 4.04 | 549.16 | 255.06 | | Liquiritin (3) | 4.07 | 417.12 | 255.06 | | Isoliquiritin apioside (6) | 4.26 | 549.16 | 255.06 | | Isoliquiritin (4) | 4.33 | 417.12 | 255.06 | | Liquiritigenin (8) | 4.56 | 255.06 | 135.01 | | Isoliquiritigenin (9) | 4.91 | 255.06 | 119.05 | | Glycyrrhizic acid (10) | 5.02 | 821.39 | 351.05 | | Glycyrrhetinic acid (11) | 6.22 | 469.33 | 425.34 | | Ginsenoside Rb1 (IS1) | 4.50 | 1107.59 | 1107.59 | | Swertiamarin (IS2) | 2.77 | 419.11 | 179.05 | | Kaempferol-3-O-rutinoside (IS3) | 4.16 | 593.15 | 285.04 |
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