Simultaneous Determination of 11 Compounds in Gualou Guizhi Granule and Pharmacokinetics Study by UPLC-MS/MS

Table 3

LLOQ and LLOD of detected compounds.

Analyte	Linear range; (μg⋅mL^−1)	LLOQ; (ng⋅mL^−1)	LLOD; (ng⋅mL^−1)
Paeoniflorin	0.04–8	11.10	3.32
Albiflorin	0.04–10	5.42	1.73
Liquiritin	0.005–1	0.11	0.03
Isoliquiritin	0.005–0.5	0.81	0.26
Liquirtin apioside	0.005–0.5	0.46	0.14
Isoliquiritin apioside	0.005–0.5	0.88	0.36
Liquiritigenin	0.001–0.2	0.55	0.20
Isoliquiritigenin	0.001–0.2	0.93	0.36
Glycyrrhizic acid	0.05–10	29.82	10.67
Glycyrrhetinic acid	0.01–4	15.74	5.95
Paeoniflorin sulfonate	0.05–11.25	4.21	1.52