Research Article
Simultaneous Determination of 11 Compounds in Gualou Guizhi Granule and Pharmacokinetics Study by UPLC-MS/MS
Table 6
The extraction recovery of detected compounds in rat plasma (
).
| | Analyte | Nominal concentration
(μg⋅mL−1) | Extraction recovery | | Mean | SD | RSD |
| | Paeoniflorin | 0.1 | 95.62% | 9.60% | 10.04% | | 2 | 89.08% | 8.29% | 9.31% | | 8 | 88.65% | 5.87% | 6.62% | | Albiflorin | 0.1 | 95.43% | 8.97% | 9.40% | | 2 | 95.33% | 10.93% | 11.47% | | 8 | 92.33% | 8.32% | 9.01% | | Liquiritin | 0.01 | 104.13% | 11.50% | 11.05% | | 0.2 | 85.14% | 7.70% | 9.04% | | 0.5 | 96.98% | 9.43% | 9.72% | | Isoliquiritin | 0.01 | 90.56% | 7.54% | 8.32% | | 0.1 | 86.10% | 8.39% | 9.74% | | 0.25 | 91.48% | 4.68% | 5.12% | | Liquirtin apioside | 0.01 | 90.38% | 8.90% | 9.85% | | 0.1 | 99.47% | 6.93% | 6.96% | | 0.25 | 90.76% | 10.23% | 11.27% | | Isoliquiritin apioside | 0.01 | 81.30% | 7.70% | 9.47% | | 0.1 | 108.22% | 7.52% | 6.95% | | 0.25 | 93.61% | 9.43% | 10.07% | | Liquiritigenin | 0.005 | 94.50% | 8.51% | 9.01% | | 0.1 | 88.01% | 6.42% | 7.29% | | 0.2 | 92.48% | 6.32% | 6.83% | | Isoliquiritigenin | 0.005 | 102.31% | 9.49% | 9.27% | | 0.02 | 101.35% | 9.76% | 9.63% | | 0.05 | 90.08% | 5.19% | 5.76% | | Glycyrrhizic acid | 0.1 | 93.11% | 8.21% | 8.82% | | 2 | 100.35% | 9.58% | 9.54% | | 8 | 99.46% | 6.38% | 6.41% | | Glycyrrhetinic acid | 0.01 | 106.28% | 7.13% | 6.71% | | 1 | 87.71% | 7.04% | 8.02% | | 2 | 103.53% | 8.93% | 8.63% | | Paeoniflorin sulfonate | 0.1 | 95.33% | 7.32% | 7.68% | | 2 | 98.05% | 6.42% | 6.55% | | 8 | 104.21% | 8.45% | 8.11% |
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