Research Article
Simultaneous Determination of 11 Compounds in Gualou Guizhi Granule and Pharmacokinetics Study by UPLC-MS/MS
Table 7
The matrix effect of detected compounds in rat plasma.
| | Analyte | Nominal concentration
(μg⋅mL−1) | Matrix effect | | Mean | SD | RSD |
| | Paeoniflorin | 0.1 | 104.05% | 4.16% | 4.00% | | 2 | 93.79% | 5.89% | 6.28% | | 8 | 98.33% | 6.01% | 6.11% | | Albiflorin | 0.1 | 101.59% | 4.26% | 4.19% | | 2 | 107.86% | 9.43% | 8.74% | | 8 | 99.29% | 5.97% | 6.02% | | Liquiritin | 0.01 | 88.91% | 6.93% | 7.79% | | 0.2 | 106.80% | 7.42% | 6.95% | | 0.5 | 102.29% | 5.04% | 4.92% | | Isoliquiritin | 0.01 | 97.40% | 5.23% | 5.37% | | 0.1 | 91.78% | 4.15% | 4.52% | | 0.25 | 98.38% | 9.32% | 9.48% | | Liquirtin apioside | 0.01 | 113.32% | 5.30% | 4.68% | | 0.1 | 105.87% | 6.20% | 5.86% | | 0.25 | 99.60% | 5.64% | 5.66% | | Isoliquiritin apioside | 0.01 | 110.04% | 3.08% | 2.80% | | 0.1 | 106.10% | 3.46% | 3.27% | | 0.25 | 100.67% | 4.21% | 4.18% | | Liquiritigenin | 0.005 | 89.86% | 6.43% | 7.16% | | 0.1 | 94.92% | 6.30% | 6.64% | | 0.2 | 99.45% | 6.61% | 6.65% | | Isoliquiritigenin | 0.005 | 108.12% | 7.51% | 6.94% | | 0.02 | 101.51% | 8.30% | 8.18% | | 0.05 | 96.87% | 4.63% | 4.78% | | Glycyrrhizic acid | 0.1 | 99.71% | 8.42% | 8.44% | | 2 | 90.76% | 8.72% | 9.61% | | 8 | 106.96% | 8.42% | 7.87% | | Glycyrrhetinic acid | 0.01 | 95.51% | 6.25% | 6.55% | | 1 | 93.47% | 4.64% | 4.97% | | 2 | 101.34% | 5.93% | 5.85% | | Paeoniflorin sulfonate | 0.1 | 100.75% | 8.54% | 8.48% | | 2 | 104.38% | 7.23% | 6.93% | | 8 | 110.07% | 6.31% | 5.73% |
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