Comparative Liquid Chromatographic Study for Concurrent Determination of Canagliflozin and Metformin in Combined Tablets

Table 3

Determination of CANA and MET in lab prepared mixtures by the proposed methods.

Mix. number	CANA	MET	CANA		MET
	Taken (µg/mL)		Found (µg/mL)	% recovery	Found (µg/mL)	% recovery
HPLC method
1	8	70	8.03	100.45	69.74	99.63
2	10	65	10.16	101.75	64.38	99.05
3	20	80	19.81	98.99	79.51	99.39
4	25	65	24.88	99.53	65.27	100.42
	3	60	2.94	98.09	59.71	99.51
	Mean ± SD
UPLC method
1	8	70	7.94	99.21	70.20	100.29
2	10	65	9.92	99.17	65.58	100.89
3	20	80	19.85	99.23	78.64	98.29
4	25	65	24.75	99.01	65.42	100.64
	3	60	3.01	100.19	59.69	99.48
	Mean ± SD

mixture represents the CANA: MET ratio as as in dosage form.