Simultaneous Quantitative Determination of Synthetic Cathinone Enantiomers in Urine and Plasma Using GC-NCI-MS

Table 3

Results for fourteen cathinone-related compounds spiked in plasma and urine including linearity coefficient, R² values, limits of detection, and limits of quantitation for the two enantiomers of each compound.

Plasma

Urine

R^2

LOQ (µg/L)

LOD (µg/L)

R^2

LOQ (µg/L)

LOD (µg/L)

E1

E2

E1

E2

E1

E2

E1

E2

E1

E2

E1

E2

1

4-FMC

0.9905

0.9962

0.957 ± 0.14

0.924 ± 0.12

0.29  ± 0.08

0.28 ± 0.08

0.9903

0.9900

1.09 ± 0.11

1.06 ± 0.11

0.33 ± 0.08

0.32 ± 0.08

2

4-FEC

0.9908

0.9902

1.023 ±  0.15

1.122 ±  0.13

0.31 ± 0.08

0.34 ± 0.08

0.9959

0.9914

1.82 ± 0.16

2.34 ± 0.16

0.55 ± 0.1

0.71 ± 0.1

3

Nor-mephedrone

0.9902

0.9931

0.891 ± 0.09

1.056 ± 0.14

0.27 ± 0.08

0.32 ± 0.08

0.9949

0.9926

2.15 ± 0.15

2.51 ± 0.16

0.65 ± 0.1

0.76 ± 0.1

4

Buphedrone

0.9933

0.9907

0.891 ± 0.09

0.858 ± 0.08

0.27 ± 0.08

0.26 ± 0.08

0.9931

0.9922

0.96 ± 0.14

0.92 ± 0.10

0.29 ± 0.07

0.28 ± 0.07

5

3-MMC

0.9904

0.9903

0.891 ± 0.09

0.858 ± 0.08

0.27  ± 0.08

0.26 ± 0.08

0.9944

0.9957

1.02 ± 0.15

0.92 ± 0.09

0.31 ± 0.08

0.28 ± 0.07

6

3-Methylbuphedrone

0.9902

0.9914

0.99 ± 0.11

1.023 ± 0.15

0.3 ± 0.08

0.31 ± 0.08

0.9941

0.9931

1.02 ± 0.15

0.99 ± 0.11

0.31 ± 0.07

0.3 ± 0.07

7

4-Methylbuphedrone

0.9910

0.9919

1.056 ± 0.10

1.056 ± 0.10

0.32 ± 0.08

0.32 ± 0.08

0.9902

0.9919

1.12 ± 0.13

1.09 ± 0.11

0.34 ± 0.09

0.33 ± 0.08

8

3-EMC

0.9945

0.9915

1.155 ± 0.11

1.089 ± 0.10

0.35 ± 0.08

0.33 ± 0.08

0.9901

0.9906

1.12 ± 0.11

1.06 ± 0.11

0.34 ± 0.08

0.32 ± 0.08

9

3-EEC

0.9952

0.9905

1.023 ± 0.11

0.957 ±  0.14

0.31 ± 0.08

0.29 ± 0.08

0.9980

0.9921

1.02 ± 0.15

1.09 ± 0.10

0.31 ± 0.07

0.33 ± 0.08

10

4-EEC

0.9942

0.9907

0.957 ± 0.14

0.858 ± 0.10

0.29 ± 0.08

0.26 ± 0.08

0.9907

0.9901

1.09 ± 0.10

1.12 ± 0.11

0.33 ± 0.08

0.34 ± 0.07

11

3,4-DMEC

0.9904

0.9909

0.99 ± 0.10

1.056 ± 0.10

0.3 ± 0.08

0.32 ± 0.08

0.9924

0.9912

1.12 ± 0.11

1.39 ± 0.11

0.34 ± 0.08

0.42 ± 0.09

12

2,3-MDMC

0.9900

0.9918

1.122 ± 0.10

1.089 ± 0.10

0.34 ± 0.08

0.33 ± 0.08

0.9927

0.9916

1.35 ± 0.13

1.35 ± 0.11

0.41 ± 0.09

0.41 ± 0.09

13

Butylone

0.9950

0.9920

0.924 ± 0.09

0.957  ±  0.14

0.28 ± 0.08

0.29 ± 0.08

0.9920

0.9908

0.86 ± 0.11

0.89 ± 0.09

0.26 ± 0.08

0.27 ± 0.07

14

Pentylone

0.9940

0.9969

0.858 ± 0.09

0.957 ± 0.14

0.26 ± 0.08

0.29 ± 0.08

0.9923

0.9901

0.96 ± 0.10

0.86 ± 0.11

0.29 ± 0.07

0.26 ± 0.08