Application of TLC for Evaluation of the Lipophilicity of Newly Synthetized Esters: Betulin Derivatives

<table class="table-group" id="tab2"><tr><td><table class="table"><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr class="thead"><td class="align_left">Compound</td><td class="align_center"><span style="width: 21.3557ptpx;"><svg height="11.9087pt" id="M19" style="vertical-align:-3.2728pt" version="1.1" viewbox="-0.0498162 -8.6359 21.3557 11.9087" width="21.3557pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M610 18C585 26 567 34 540 68C517 97 499 128 476 171C452 215 425 276 413 304C496 332 570 394 570 494C570 555 545 595 509 619S419 650 364 650H139L133 622C216 615 219 612 203 527L129 132C112 40 105 36 23 28L17 0H279L285 28C199 34 194 40 211 132L239 284H284C320 284 334 275 351 236C374 182 394 140 420 93C459 23 495 -1 592 -8H600L610 18ZM480 485C480 424 449 372 403 342C374 323 338 316 293 316H245L291 562C296 589 301 601 311 608S337 618 358 618C432 618 480 575 480 485Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,8.086,3.132)"><path d="M861 0V28C774 35 771 41 768 147L759 509C756 612 762 614 851 622V650H681L449 149L221 650H57V622C148 613 153 609 144 479L130 271C123 166 117 123 111 88C104 46 85 34 26 28V0H259V28C192 35 169 42 167 90C166 130 166 173 170 256L185 541H187L411 7H431L675 555H679L683 147C683 41 680 35 598 28V0H861Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,16.194,3.132)"><path d="M248 635C97 635 43 457 43 311C43 153 97 -12 247 -12S450 166 450 312C450 466 397 635 248 635ZM246 603C337 603 361 452 361 312S337 20 248 20S132 172 132 313C132 452 156 603 246 603Z"></path></g></svg></span></td><td class="align_center"><i>b</i></td><td class="align_center"><i>r</i></td><td class="align_center"><span style="width: 45.9043ptpx;"><svg height="12.0392pt" id="M20" style="vertical-align:-3.4033pt" version="1.1" viewbox="-0.0498162 -8.6359 45.9043 12.0392" width="45.9043pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g 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293C396 328 384 360 366 381L423 378C439 387 459 413 468 429L463 437ZM219 418C277 418 314 362 314 284C314 205 275 166 231 165C176 165 137 221 137 299C137 376 177 418 219 418ZM241 -11C285 -11 314 -14 339 -24C367 -36 384 -61 384 -95C384 -157 335 -206 240 -206C166 -206 108 -165 108 -110C108 -82 128 -54 154 -32C172 -17 195 -11 241 -11Z"></path></g><g transform="matrix(.013,0,0,-0.013,22.075,0)"><path d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 607 210 531L130 127C113 41 106 36 23 28L17 0H294L300 28C204 36 195 42 212 127L243 284L314 263C327 263 339 263 352 264C465 271 600 337 600 480ZM508 481C508 351 402 304 329 304C289 304 265 311 250 317L295 559C302 594 310 606 323 611C335 616 350 619 367 619C455 619 508 573 508 481Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,28.731,3.132)"><path d="M592 498C586 556 582 629 581 675H560C545 656 537 650 510 650H115C87 650 74 652 60 675H40C38 620 33 555 28 495H57C69 539 77 568 89 585C102 607 122 616 205 616H267V123C267 44 259 34 168 28V0H454V28C360 34 352 44 352 123V616H422C498 616 514 608 531 584C542 568 552 543 562 495L592 498Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,34.345,3.132)"><path d="M495 163C480 117 462 85 444 65C421 39 387 34 332 34C290 34 256 36 236 47C218 57 213 77 213 131V526C213 612 222 616 301 622V650H40V622C122 616 128 611 128 526V126C128 41 120 34 36 28V0H489C498 31 519 126 525 157L495 163Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,39.168,3.132)"><path d="M614 175C564 76 510 21 408 21C256 21 146 149 146 336C146 488 235 629 402 629C510 629 570 586 597 480L626 488C620 541 614 582 606 638C578 643 510 665 429 665C206 665 44 527 44 316C44 157 153 -15 402 -15C474 -15 558 5 586 11C604 45 629 119 643 165L614 175Z"></path></g></svg></span></td></tr><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr><td class="align_left"><b>1</b></td><td class="align_center">6.26</td><td class="align_center">−0.07</td><td class="align_center">0.990</td><td class="align_center">7.68</td></tr><tr><td class="align_left"><b>2</b></td><td class="align_center">6.31</td><td class="align_center">−0.07</td><td class="align_center">0.995</td><td class="align_center">7.74</td></tr><tr><td class="align_left"><b>3</b></td><td class="align_center">7.76</td><td class="align_center">−0.08</td><td class="align_center">0.994</td><td class="align_center">9.43</td></tr><tr><td class="align_left"><b>4</b></td><td class="align_center">7.97</td><td class="align_center">−0.08</td><td class="align_center">0.996</td><td class="align_center">9.68</td></tr><tr class="table-tr"><td colspan="5"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td><div><i>b</i> is the slope, and <i>r</i> is the correlation coefficient for the linear relationship <i>R</i><sub>M</sub> = <i>R</i><sub>M0</sub> + <i>b</i>C.<br/></div></td></tr></table>

<div>The experimental values of lipophilicity for investigated compounds <b>1</b>–<b>4</b> in the mobile phase acetone-Tris buffer.</div>

Journal of Analytical Methods in Chemistry

tab2

Table 2

Table 2: Application of TLC for Evaluation of the Lipophilicity of Newly Synthetized Esters: Betulin Derivatives 