Simultaneous Determination of Five Chromones of Radix Saposhnikoviae Extract in Rat Plasma by UPLC-MS/MS: Application to a Comparative Pharmacokinetic Study in Normal and Febrile Rats

Figure 2

Representative MRM chromatograms of (a) prim-O-glucosylcimifugin, (b) cimifugin, (c) 4′-O-β-D-glucosyl-5-O-methylvisamminol, (d) 5-O-methylvisamminol, (e) sec-O-glucosylhamaudol, (f) IS in (I) blank plasma, (II) blank plasma spiked with the analytes at the LLOQ and IS, and (III) rat plasma sample obtained at 1 h after oral administration of RS extract.

(a)

(b)

(c)

(d)

(e)

(f)