Simultaneous Determination of Five Chromones of Radix Saposhnikoviae Extract in Rat Plasma by UPLC-MS/MS: Application to a Comparative Pharmacokinetic Study in Normal and Febrile Rats

Table 5

Pharmacokinetic parameters in normal and febrile rats after oral administration of Radix Saposhnikoviae (RS) extract (mean ± SD, ).

Group	Analytes	T1/2 (min)	Tmax (min)	Cmax (μg/mL)	AUC0–t (μg/mL ∗ min)	AUC0–∞ (μg/mL ∗ min)
Normal	Prim-O-glucosylcimifugin	2.84 ± 0.85	0.50 ± 0.00	0.36 ± 0.07	0.54 ± 0.07	0.56 ± 0.08
	Cimifugin	8.08 ± 4.59	6.00 ± 1.27	1.86 ± 0.18	27.50 ± 1.99	32.61 ± 6.41
	4′-O-β-D-glucosyl-5-O-methylvisammino	1.67 ± 0.38	0.47 ± 0.07	0.11 ± 0.01	0.17 ± 0.04	0.18 ± 0.05
	5-O-methylvisammino	6.35 ± 2.87	8.33 ± 0.82	0.38 ± 0.09	4.47 ± 0.99	5.08 ± 0.74
	Sec-O-glucosylhamaudol	20.54 ± 16.51	0.42 ± 0.14	0.05 ± 0.01	0.13 ± 0.02	0.15 ± 0.04
Model	Prim-O-glucosylcimifugin	11.59 ± 7.49	0.31 ± 0.07	0.46 ± 0.06	0.66 ± 0.12	0.67 ± 0.12
	Cimifugin	7.79 ± 2.92	2.17 ± 0.41	2.29 ± 0.18	26.85 ± 1.41	32.03 ± 4.67
	4′-O-β-D-glucosyl-5-O-methylvisammino	7.41 ± 6.60	0.33 ± 0.00	0.15 ± 0.01	0.23 ± 0.02	0.24 ± 0.03
	5-O-methylvisammino	6.21 ± 1.20	8.67 ± 1.03	0.40 ± 0.05	5.04 ± 0.38	5.68 ± 0.58
	Sec-O-glucosylhamaudol	6.99 ± 3.86	0.36 ± 0.07	0.05 ± 0.01	0.13 ± 0.01	0.14 ± 0.01