Pharmacokinetic Comparisons of Eight Active Components from Raw Farfarae Flos and Honey-Processed Farfarae Flos after Oral Administration in Rats by UHPLC-MS/MS Approaches

Table 5

Stability of 8 analytes and IS in rat plasma (n = 3).

Analytes	Concentration (ng/mL)	Short-term (RE%)	Long-term (RE%)	Freeze-thaw (RE%)
Ferulic acid	100.00	2.02	2.16	4.78
	200.00	−0.51	3.51	1.65
	500.00	0.79	1.03	1.23
Caffeic acid	380.00	−3.53	−3.82	4.73
	3800.00	1.00	1.23	4.70
	6000.00	1.03	1.97	1.01
Chlorogenic acid	3500.00	0.12	−2.47	−1.34
	40400.00	1.78	−1.56	−1.72
	110000.00	−2.36	−2.94	−2.67
Neochlorogenic acid	1000.00	2.04	2.83	4.96
	15000.00	0.62	−4.71	2.35
	25000.00	1.47	2.60	−3.54
Cryptochlorogenic acid	2000.00	2.36	1.02	1.73
	50000.00	1.54	3.73	1.67
	100000	2.25	2.06	3.86
Isochlorogenic acid B	2000.00	−0.21	2.84	2.90
	80000.00	1.10	2.06	1.59
	160000.00	1.41	−2.26	−1.12
Isochlorogenic acid C	1500.00	1.31	4.77	2.78
	7500.00	−0.29	1.42	3.65
	140000.00	0.87	3.63	2.79
Rutin	600.00	−0.53	−4.09	−2.83
	4000.00	0.77	3.92	−1.23
	8000.00	1.23	3.30	2.31
Chloramphenicol (IS)	100	0.74	−2.22	−4.77