Pharmacokinetic Comparisons of Eight Active Components from Raw Farfarae Flos and Honey-Processed Farfarae Flos after Oral Administration in Rats by UHPLC-MS/MS Approaches

Table 6

Pharmacokinetic parameters of the 8 compounds in rats after oral administration of R-FF extracts (mean ± SD, n = 6).

Compound name	Cmax (ng/mL)	Tmax (h)	t1/2 (h)	AUC0–t (ng/L)	AUC0–∞ (ng/L)	MRT0–t (h)
Caffeic acid	4466.83 ± 310.88	0.33 ± 0.00	32.31 ± 17.62	20170.48 ± 405.49	35243.49 ± 9993.30	14.33 ± 0.25
Ferulic acid	252.591 ± 25.68	0.33 ± 0.00	5.07 ± 1.87	852.73 ± 29.44	2142.091 ± 195.59	4.21 ± 0.11
Chlorogenic acid	75585.07 ± 3061.79	0.33 ± 0.00	33.39 ± 3.36	167278.14 ± 21752.90	236184.38 ± 75589.19	10.62 ± 0.82
Cryptochlorogenic acid	67806.79 ± 3098.94	0.33 ± 0.00	21.85 ± 9.25	169993.99 ± 5978.78	242406.33 ± 49101.77	11.19 ± 0.53
Neochlorogenic acid	14852.03 ± 2370.78	0.33 ± 0.00	30.13 ± 6.85	56034.70 ± 4221.63	86956.297 ± 8336.51	12.53 ± 1.19
Isochlorogenic acidB	25184.90 ± 1591.85	0.33 ± 0.00	9.68 ± 1.36	193886.50 ± 6583.48	200747.374 ± 7208.02	10.91 ± 1.04
Isochlorogenic acid C	12916.78 ± 3117.99	0.33 ± 0.00	20.36 ± 5.22	110510.52 ± 9500.31	119513.50 ± 7705.49	14.32 ± 1.56
Rutin	7431.05 ± 446.28	0.33 ± 0.00	30.73 ± 14.04	100474.64 ± 9127.45	211030.24 ± 37905.16	18.91 ± 0.17