Pharmacokinetic Comparisons of Eight Active Components from Raw Farfarae Flos and Honey-Processed Farfarae Flos after Oral Administration in Rats by UHPLC-MS/MS Approaches

Table 7

Pharmacokinetic parameters of the 8 compounds in rats after oral administration of H-FF extracts (mean ± SD, n = 6).

Compound name	Cmax (ng/mL)	Tmax (h)	t1/2 (h)	AUC0–t (ng/L)	AUC0–∞ (ng/L)	MRT0–t (h)
Caffeic acid	4546.03 ± 234.68	0.33 ± 0.00	78.91 ± 26.02	24077.72 ± 2058.94	66775.53 ± 12172.05	12.74 ± 0.38
Ferulic acid	380.29 ± 5.89	0.33 ± 0.00	3.31 ± 0.68	1755.91 ± 224.17	2253.06 ± 441.77	3.33 ± 0.11
Chlorogenic acid	80426.52 ± 6354.93	0.33 ± 0.00	32.87 ± 4.87	280872.79 ± 10762.66	428350.92 ± 41590.65	11.10 ± 0.16
Cryptochlorogenic acid	97347.78 ± 1148.09	0.33 ± 0.00	17.57 ± 1.57	350674.18 ± 16655.08	401169.15 ± 21996.95	13.22 ± 0.39
Neochlorogenic acid	24733.36 ± 3224.91	0.33 ± 0.00	14.72 ± 3.88	95663.97 ± 6559.48	116684.574 ± 15910.07	10.87 ± 0.44
Isochlorogenic acid B	52292.60 ± 3007.78	0.33 ± 0.00	16.77 ± 5.09	388737.23 ± 24473.56	455375.91 ± 14598.23	15.19 ± 0.19
Isochlorogenic acid C	28183.80 ± 3739.61	0.33 ± 0.00	22.14 ± 9.73	186463.54 ± 18492.14	231840.44 ± 35996.24	16.42 ± 0.84
Rutin	7035.33 ± 429.34	0.39 ± 0.09	14.28 ± 2.28	64616.54 ± 4911.51	105151.44 ± 9984.91	22.73 ± 0.82