Comparative Pharmacokinetic Profiles of Puerarin in Rat Plasma by UHPLC-MS/MS after Oral Administration of Pueraria lobata Extract and Pure Puerarin

Table 5

Pharmacokinetic parameters of PUR in rat plasma after oral administration of PUR at a dose of 100 mg/kg and PLE at a dose of 763 mg/kg. (n = 6, mean ± SD).

Parameters	Units	PUR	PLE
AUC0-t	μg·h/L	213.09 ± 61.91	406.30 ± 53.68
AUC0-inf	μg·h/L	219.83 ± 64.37	462.62 ± 51.74
MRT0-t	h	2.22 ± 0.46	11.28 ± 0.79
t1/2	h	1.60 ± 0.38	12.04 ± 5.10
Tmax	h	1.46 ± 1.08	0.54 ± 0.30
CLz/F	L/h/kg	508.66 ± 202.54	217.30 ± 25.04
Vz/F	L/kg	1198.32 ± 403.31	3738.75 ± 1436.17
Cmax	μg/L	101.64 ± 41.82	48.64 ± 21.47

; , compared with the PUR group.