Simultaneous Determination of 34 Amino Acids in Tumor Tissues from Colorectal Cancer Patients Based on the Targeted UHPLC-MS/MS Method

Table 1

The summarized variations of amino acids in blood, urine, feces, and cancerous tissue of CRC patients.

Amino acids	Variations				References
	In blood	In urine	In feces	In tissue^#
Gly	↓			↑	[1, 2]
Ala		↑		↑	[3–5]
Ser	↑	↓			[3, 6, 7]
Val	↓	↑			[2, 6, 7]
Thr	↓				[2]
Leu	↓↑	↑			[3, 5–7]
Ile		↑			[6–8]
Asp	↓↑	↓		↑	[3, 4, 6, 7, 9]
Gln	↓	↑			[3, 8]
Glu	↑			↑	[4, 8, 9]
Phe	↓			↑	[3, 10]
Arg		↑			[6, 7]
Tyr		↑		↑	[3, 10]
Pro	↓		↑	↑	[3, 11, 12]
Met	↓	↓			[5–7]
Trp		↑			[3]
Cys			↑	↑	[4, 11]
His	↓	↓			[3, 6, 7]
Cit	↑				[3]
ADMA	↑				[13–15]
Cyss	↑				[9]
Aba				↑	[16, 17]
Opr				↑	[4]
Hpr	↓				[3]
Orn	↑				[3]
Ahd	↓				[5]
Hia	↑	↓			[5, 18]
SDMA	↑				[14, 15]
Kyn	↑	↓			[9, 18]

Note. CRC patients vs. healthy volunteers; ↑: increase; ↓: decrease; ↓↑: increase and decrease. ^#The cancerous tissue of CRC patients vs. the normal tissue of CRC patients.