Coordination of Nanoconjugation with an Antigen/Antibody for Efficient Detection of Gynecological Tumors

Figure 5

(a) Comparison of the difference in current changes with various concentrations of SCC-Ag. Methods of SCC-Ag-GNP on the antibody and SCC-Ag on SCC-Ag-antibody-GNP surfaces were considered. Both methods show significant changes in the current from 62.5 fM and saturated at 1 pM SCC-Ag. (b) Linear regression analysis for the interaction of different concentrations of SCC-Ag-GNP with ASC-Ag-antibody and SCC-Ag with SCC-Ag-antibody-GNP. The sensitivity was calculated based on 3σ as indicated. The calculated sensitivities are 125 and 62.5 fM for methods 1 and 2, respectively.

(a)

(b)