Establishment of a UPLC-MS/MS Method for Studying the Effect of Salt-Processing on Tissue Distribution of Twelve Major Bioactive Components of Qing’e Pills in Rats

Figure 2

SIM chromatograms of 12 active ingredients and IS in rat tissue. (a) Blank tissue; (b) blank tissue spiked with standard solution and IS; (c) kidney tissue samples after intragastric administration of crude Qing’e pills; and (d) kidney tissue samples of oral administration of salt-processed Qing’e pills (1. Escoparone, 2. psoralenoside, 3. psoralen, 4. Isopsoralen, 5. isobavachin, 6. bavachin, 7. bavachalcone, 8. isobavachalcone, 9. pinoresinol diglucoside, 10. rhein, 11. geniposidic acid, 12. psoralidin, 13. neobavaisoflavone, and 14. bavachinin).

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