Pharmacokinetic Comparisons of Different Combinations of Yigan Jiangzhi Formula in Rats: Simultaneous Determination of Fourteen Components by UPLC-MS/MS

Table 1

Optimized MS/MS transitions, parameters, and retention time of the analytes and internal standards.

No.	Analytes	Ion mode	Parent (m/z)	Daughter (m/z)	Cone (V)	Collision (eV)	Retention time (min)
1	Daidzein	ES+	254.9	91.0	52	40	3.06
2	Fermononetin	ES+	268.9	196.9	56	40	4.37
3	Apigenin	ES+	270.9	152.9	62	30	3.68
4	Luteolin	ES+	286.9	152.9	66	32	3.18
5	Berberine	ES+	336.0	277.9	12	44	3.12
6	Jatrorrhizin	ES+	338.0	280.3	52	40	2.75
7	Palmatine	ES+	352.0	279.0	54	54	3.05
8	Puerarin	ES+	416.9	296.9	46	24	1.84
9	Ononin	ES+	430.9	269.0	28	16	2.81
10	Calycosin-7-O-β-D-Glc	ES+	446.9	284.9	32	24	2.25
11	Tanshinol	ES−	197.0	122.9	24	20	1.44
12	Rosmarinic acid	ES−	359.0	160.9	32	18	2.64
13	Alkanoic acid	ES−	537.0	295.0	20	22	2.62
14	Salvianolic acid B	ES−	717.0	518.9	38	20	2.72
IS1	Liquiritigenin	ES+	257.0	136.9	38	24	3.15
IS2	Hesperidin	ES−	609.1	301.0	46	24	2.50