Pharmacokinetic Comparisons of Different Combinations of Yigan Jiangzhi Formula in Rats: Simultaneous Determination of Fourteen Components by UPLC-MS/MS

Table 7

PK parameters of the fourteen analytes after oral administration of dose-1 and dose-2 of YGJZF (mean ± SD, n = 6).

No.	Analyte	Group	Tmax (h)	Cmax (ng/mL)	T1/2 (h)	AUC0−t (ng h/mL)	AUC0−∞ (ng h/mL)	MRT0−t (h)	CL (L/kg/h)
1	Daidzein	Dose-1	7.00 ± 0.00	70.60 ± 13.24	21.73 ± 5.42	892.44 ± 140.57	957.28 ± 166.21	17.37 ± 1.25	1.11 ± 0.18
		Dose-2	11.57 ± 1.13	185.67 ± 17.55	18.99 ± 6.25	2929.33 ± 356.15	3062.05 ± 336.23	16.98 ± 0.80	0.74 ± 0.08
2	Fermononetin	Dose-1	0.50 ± 0.00	9.62 ± 0.75	5.55 ± 1.41	25.07 ± 5.53	30.65 ± 6.86	3.75 ± 0.23	3.82 ± 0.84
		Dose-2	0.50 ± 0.00	23.42 ± 4.38	7.35 ± 1.03	48.16 ± 6.59	64.12 ± 8.47	3.66 ± 0.21	3.81 ± 0.98
3	Apigenin	Dose-1	7.33 ± 0.82	2.27 ± 0.37	5.19 ± 1.18	20.08 ± 3.50	22.06 ± 4.61	9.54 ± 0.46	1.06 ± 0.22
		Dose-2	11.57 ± 1.13	5.43 ± 0.95	11.07 ± 2.53	73.03 ± 8.18	87.12 ± 12.08	12.54 ± 0.69	0.43 ± 0.22
4	Luteolin	Dose-1	6.00 ± 1.10	5.83 ± 0.36	5.91 ± 1.03	62.24 ± 11.28	67.85 ± 6.61	9.39 ± 0.35	0.83 ± 0.15
		Dose-2	11.14 ± 1.46	9.44 ± 1.91	9.12 ± 1.96	128.32 ± 22.28	136.04 ± 20.17	12.05 ± 0.58	0.59 ± 0.17
5	Berberine	Dose-1	0.33 ± 0.00	10.92 ± 1.53	28.57 ± 3.83	60.82 ± 14.40	98.58 ± 12.98	24.43 ± 3.17	68.22 ± 14.22
		Dose-2	0.17 ± 0.00	19.54 ± 4.16	29.84 ± 5.08	82.99 ± 17.38	136.71 ± 19.25	19.28 ± 1.80	108.48 ± 21.26
6	Jatrorrhizin	Dose-1	0.50 ± 0.00	2.80 ± 0.54	5.21 ± 1.92	5.76 ± 1.15	7.53 ± 0.88	2.97 ± 0.10	142.45 ± 14.22
		Dose-2	0.17 ± 0.00	5.96 ± 1.02	9.01 ± 2.40	9.39 ± 1.67	15.60 ± 2.56	2.96 ± 0.36	111.50 ± 18.20
7	Palmatine	Dose-1	0.50 ± 0.00	6.56 ± 1.44	5.18 ± 1.01	22.80 ± 5.20	27.80 ± 6.08	4.07 ± 0.19	64.39 ± 12.97
		Dose-2	0.17 ± 0.00	13.00 ± 2.51	9.58 ± 1.92	53.12 ± 4.17	59.16 ± 10.41	3.90 ± 0.29	67.30 ± 13.15
8	Puerarin	Dose-1	0.47 ± 0.07	700.35 ± 88.69	18.22 ± 2.70	3658.38 ± 441.21	3835.09 ± 486.41	14.68 ± 2.00	33.56 ± 4.30
		Dose-2	0.26 ± 0.09	1474.99 ± 224.25	21.54 ± 5.83	5930.15 ± 614.81	6364.14 ± 655.14	15.28 ± 1.27	26.81 ± 2.71
9	Ononin	Dose-1	0.17 ± 0.00	6.73 ± 0.61	2.65 ± 0.51	14.87 ± 2.08	17.46 ± 1.68	2.41 ± 0.23	67.12 ± 6.57
		Dose-2	0.17 ± 0.00	15.05 ± 3.46	4.69 ± 1.48	20.11 ± 3.53	28.77 ± 6.34	2.20 ± 0.28	76.29 ± 10.10
10	Calycosin-7-O-β-D-Glc	Dose-1	0.50 ± 0.00	3.30 ± 0.13	3.85 ± 1.68	5.08 ± 0.62	6.38 ± 0.75	2.06 ± 0.17	142.62 ± 16.25
		Dose-2	0.17 ± 0.00	9.01 ± 1.66	6.79 ± 2.28	8.47 ± 1.96	11.64 ± 2.04	1.57 ± 0.12	123.81 ± 24.03
11	Tanshinol	Dose-1	0.75 ± 0.00	182.69 ± 21.72	3.70 ± 0.72	437.71 ± 97.41	508.99 ± 105.81	2.59 ± 0.08	12.65 ± 2.76
		Dose-2	0.17 ± 0.00	637.19 ± 71.44	7.85 ± 2.62	1365.06 ± 292.73	2169.55 ± 523.01	2.93 ± 0.31	4.74 ± 1.23
12	Rosmarinic acid	Dose-1	0.50 ± 0.00	89.13 ± 13.69	1.61 ± 0.44	149.22 ± 22.98	152.56 ± 21.53	2.02 ± 0.19	63.35 ± 9.20
		Dose-2	0.17 ± 0.00	170.94 ± 37.20	5.39 ± 1.27	283.95 ± 66.86	319.74 ± 51.17	2.68 ± 0.24	30.60 ± 6.86
13	Alkanoic acid	Dose-1	1.00 ± 0.00	14.30 ± 1.73	4.92 ± 1.81	83.18 ± 10.47	103.70 ± 14.48	4.50 ± 0.22	14.65 ± 2.80
		Dose-2	0.50 ± 0.00	27.27 ± 3.89	9.06 ± 2.28	99.73 ± 19.49	150.73 ± 21.69	4.22 ± 0.19	10.03 ± 2.31
14	Salvianolic acid B	Dose-1	0.50 ± 0.00	56.12 ± 10.41	3.09 ± 0.72	95.12 ± 15.15	105.11 ± 14.37	2.31 ± 0.26	130.09 ± 17.78
		Dose-2	0.17 ± 0.00	86.06 ± 13.74	5.08 ± 1.43	96.72 ± 16.56	117.56 ± 23.28	2.10 ± 0.28	140.23 ± 27.20

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