Simultaneous Quantification of Four Ginsenosides in Rat Plasma and Its Application to a Comparative Pharmacokinetic Study in Normal and Depression Rats Using UHPLC-MS/MS

Table 3

Summary of intraday and interday precisions, accuracies, extraction recoveries, and matrix effects of the four analytes in rat plasma (n = 6).

Analytes	Concentration (ng/mL)	Intraday RSD (%)	Interday RSD (%)	Accuracy (RE%)	Recovery (%)	Matrix effect (%)
G-Rh1	25	9.43	9.69	0.58	90.65 ± 2.34	95.67 ± 2.45
	250	0.95	0.49	3.84	93.67 ± 4.08	87.37 ± 8.45
	2500	1.21	2.95	4.08	96.59 ± 0.62	97.57 ± 3.11
G-Rb1	25	6.65	6.21	−3.47	86.06 ± 2.57	91.33 ± 0.96
	250	0.98	4.56	−1.44	91.86 ± 2.25	94.22 ± 1.47
	2500	3.50	2.38	2.38	94.19 ± 1.55	95.55 ± 1.22
G-Rc	25	5.35	6.21	−7.44	89.46 ± 5.13	89.42 ± 3.17
	250	4.38	3.28	6.34	91.28 ± 4.56	94.43 ± 5.85
	2500	3.86	4.61	−6.51	93.60 ± 2.02	96.85 ± 7.33
G-Rd	25	6.29	4.82	−8.92	87.64 ± 4.87	91.78 ± 5.38
	250	1.65	2.20	−5.12	90.87 ± 0.56	96.65 ± 3.97
	2500	3.87	4.51	7.70	96.86 ± 5.08	89.94 ± 3.77