Simultaneous Quantification of Four Ginsenosides in Rat Plasma and Its Application to a Comparative Pharmacokinetic Study in Normal and Depression Rats Using UHPLC-MS/MS

Table 5

Pharmacokinetic parameters of the four analytes in the normal and model group.

Parameters	G-Rh1	G-Rb1	G-Rc	G-Rd
Normal
Cmax (mg/L)	15.163 ± 0.815	349.840 ± 6.238	7.741 ± 0.366	97.458 ± 1.800
Tmax (h)	0.50 ± 0.01	1.00 ± 0.01	1.00 ± 0.01	1.00 ± 0.01
AUC 0-72 (mg/Lh)	128.871 ± 68.509	10399.870 ± 5196.010	228.760 ± 110.731	2061.658 ± 1011.618
AUC 0-∞ (mg/Lh)	129.100 ± 68.507	10585.975 ± 5201.551	229.541 ± 110.102	2062.555 ± 1011.536
t1/2 (h)	10.731 ± 0.905	17.774 ± 0.207	9.659 ± 1.093	9.631 ± 0.206
CLz/F (L/h/kg)	621.227 ± 54.664	17.096 ± 0.382	647.808 ± 36.107	64.895 ± 2.255
MRT (h)	22.278 ± 10.621	15.952 ± 0.851	16.111 ± 2.798	13.997 ± 0.390
Model
Cmax (mg/L)	20.010 ± 1.027	385.694 ± 8.339	12.497 ± 0.809	104.959 ± 5.034
Tmax (h)	0.50 ± 0.01	1.00 ± 0.02	1.00 ± 0.01	1.00 ± 0.03
AUC 0–72 (mg/Lh)	148.939 ± 62.329	26347.000 ± 13042.423	295.337 ± 165.908	2583.439 ± 1254.680
AUC 0-∞ (mg/Lh)	149.172 ± 62.330	29419.304 ± 12850.460	295.641 ± 166.081	2587.285 ± 1253.860
t1/2 (h)	9.765 ± 0.825	13.472 ± 0.588	8.166 ± 0.881	10.198 ± 0.511
CLz/F (L/h/kg)	544.957 ± 6.150	11.994 ± 0.385	450.788 ± 23.974	55.744 ± 2.366
MRT (h)	16.589 ± 1.745	19.683 ± 0.793	14.639 ± 0.190	15.126 ± 0.671

Data were reported as mean ± SD for n = 6. , , compared with the normal group.