Research Article
Tissue Distribution of Total Flavonoids Extracts of Drynariae Rhizoma in Young and Old Rats by UPLC–MS/MS Determination
Table 2
The linear equations and range of seven analytes in different rats’ tissues.
| | Analytes | Tissue | Regression equation | Correlation coefficient | Concentration range (ng/mL) | Standard error (slope) | Standard error (intercept) |
| | Neoeriocitrin | Heart | y = 0.9013x + 5.1928 | R2 = 0.9991 | 5–500 | 4.0987 | 0.0146 | | Liver | y = 0.0972x + 36.321 | R2 = 0.9991 | 10–5,000 | 3.8552 | 0.0014 | | Spleen | y = 0.0931x + 11.703 | R2 = 0.9997 | 5–10,000 | 4.6785 | 0.0008 | | Lung | y = 0.1685x + 12.194 | R2 = 0.9990 | 10–10,000 | 5.9655 | 0.4775 | | Kidney | y = 1.195x + 5.4235 | R2 = 0.9997 | 5–500 | 4.0379 | 0.0144 | | Brain | y = 2.7542x − 1.5057 | R2 = 0.9991 | 5–100 | 2.5959 | 0.0464 | | Stomach | y = 0.1753x + 20.86 | R2 = 0.9992 | 5–10,000 | 10.5855 | 0.0023 | | Uterus | y = 1.5008x − 4.2356 | R2 = 0.9991 | 5–500 | 7.4003 | 0.0265 | | Ovary | y = 1.8168x − 7.1718 | R2 = 0.9994 | 5–500 | 7.3924 | 0.0264 | | Intestine | y = 0.0948x + 22.078 | R2 = 0.9992 | 5–10,000 | 5.9586 | 0.0013 | | Luteolin-7-O-β-D-glucoside | Heart | y = 17.011x − 11.593 | R2 = 0.9996 | 2–50 | 5.3807 | 0.1925 | | Liver | y = 14.803x − 5.3733 | R2 = 0.9996 | 2–50 | 4.6633 | 0.1668 | | Spleen | y = 19.649x − 27.686 | R2 = 0.9992 | 2–50 | 8.9679 | 0.3209 | | Lung | y = 27.742x + 144.06 | R2 = 0.9990 | 5–100 | 18.3343 | 0.5063 | | Kidney | y = 22.7x − 30.98 | R2 = 0.9992 | 2–50 | 10.4027 | 0.3722 | | Brain | y = 17.311x − 0.2042 | R2 = 0.9995 | 2–50 | 6.0981 | 0.2182 | | Stomach | y = 25.13x − 45.82 | R2 = 0.9997 | 5–100 | 14.4218 | 0.2579 | | Uterus | y = 22.459x − 27.379 | R2 = 0.9993 | 2–50 | 9.7807 | 0.3500 | | Ovary | y = 15.526x − 28.948 | R2 = 0.9995 | 2–50 | 5.2243 | 0.1869 | | Intestine | y = 23.444x − 62.646 | R2 = 0.9990 | 5–100 | 3.2885 | 0.4166 |
| | Astragalin | Heart | y = 33.567x − 145.2 | R2 = 0.9998 | 5–100 | 14.7494 | 0.2638 | | Liver | y = 28.213x − 115.87 | R2 = 0.9991 | 5–100 | 27.4261 | 0.4906 | | Spleen | y = 38.234x − 66.065 | R2 = 0.9998 | 2–50 | 8.4768 | 0.3033 | | Lung | y = 52.063x − 119.94 | R2 = 0.9991 | 5–100 | 10.7568 | 0.2546 | | Kidney | y = 18.133x − 32.32 | R2 = 0.9993 | 2–50 | 7.7062 | 0.2757 | | Brain | y = 5.7194x + 13.483 | R2 = 0.9994 | 2–50 | 2.3118 | 0.0827 | | Stomach | y = 52.209x − 32.98 | R2 = 0.9991 | 5–250 | 9.2349 | 0.9419 | | Uterus | y = 43.952x − 104.76 | R2 = 0.9993 | 5–50 | 8.5206 | 0.6613 | | Ovary | y = 33.871x − 78.24 | R2 = 0.9993 | 5–100 | 5.5678 | 0.5468 | | Intestine | y = 41.795x − 203.61 | R2 = 0.9991 | 5–100 | 4.2632 | 0.0762 |
| | Naringin | Heart | y = 8.8875x − 16.6369 | R2 = 0.9990 | 5–1,000 | 3.0936 | 0.0878 | | Liver | y = 2.2546x − 2.937 | R2 = 0.9996 | 10–10,000 | 7.5588 | 0.0015 | | Spleen | y = 2.3615x + 62.727 | R2 = 0.9992 | 5–10,000 | 7.5326 | 0.0057 | | Lung | y = 2.7462x + 20.433 | R2 = 0.9997 | 5–10,000 | 1.0489 | 0.0839 | | Kidney | y = 1.4648x + 125.32 | R2 = 0.9993 | 5–10,000 | 10.7813 | 0.0128 | | Brain | y = 5.1578x +9.1048 | R2 = 0.9990 | 5–1,000 | 4.0361 | 0.0388 | | Stomach | y = 2.4286x + 376.32 | R2 = 0.9993 | 5–20,000 | 14.1719 | 0.0236 | | Uterus | y = 3.9995x + 43.448 | R2 = 0.9990 | 5–5,000 | 9.2749 | 0.0171 | | Ovary | y = 1.6439x + 171.55 | R2 = 0.9995 | 5–10,000 | 8.4004 | 0.0075 | | Intestine | y = 2.4255x + 344.31 | R2 = 0.9990 | 5–20,000 | 4.4006 | 0.0207 |
| | Eriodictyol | Liver | y = 25.147x − 94.45 | R2 = 0.9994 | 5–100 | 6.1292 | 0.1096 | | Spleen | y = 9.1535x − 8.4711 | R2 = 0.9995 | 2–50 | 1.4348 | 0.0513 | | Lung | y = 16.877x − 61.056 | R2 = 0.9992 | 5–100 | 7.2109 | 0.1289 | | Stomach | y = 26.831x − 85.59 | R2 = 0.9991 | 5–250 | 10.1807 | 0.1236 | | Uterus | y = 11.401x − 3.982 | R2 = 0.9995 | 2–50 | 5.3807 | 0.1925 | | Ovary | y = 18.425x − 65.716 | R2 = 0.9992 | 5–100 | 4.4218 | 0.2579 | | Intestine | y = 25.138x − 3.45 | R2 = 0.9993 | 5–250 | 4.3516 | 0.3611 |
| | Naringenin | Heart | y = 21.6837x + 27.6507 | R2 = 0.9996 | 5–250 | 9.4029 | 0.1579 | | Liver | y = 27.289x + 323.82 | R2 = 0.9995 | 5–1,000 | 6.6046 | 0.2573 | | Spleen | y = 25.421x − 23.549 | R2 = 0.9991 | 5–250 | 6.4353 | 0.3780 | | Lung | y = 36.466x − 98.509 | R2 = 0.9992 | 5–250 | 3.8363 | 0.1696 | | Kidney | y = 20.267x + 108.13 | R2 = 0.9990 | 5–250 | 8.1007 | 0.3102 | | Brain | y = 5.1578x +9.1048 | R2 = 0.9990 | 2–50 | 2.5110 | 0.0898 | | Stomach | y = 23.599x + 267.38 | R2 = 0.9996 | 5–1,000 | 6.5617 | 0.2572 | | Uterus | y = 27.424x − 20.783 | R2 = 0.9990 | 5–250 | 1.1989 | 0.0976 | | Ovary | y = 29.424x − 112.58 | R2 = 0.9995 | 5–250 | 1.1010 | 0.0822 | | Intestine | y = 30.804x − 2.1048 | R2 = 0.9991 | 5–1,000 | 1.3461 | 0.2736 |
| | Kaempferol | Liver | y = 13.699x − 62.076 | R2 = 0.9992 | 5–100 | 9.1285 | 0.2192 | | Spleen | y = 10.466x − 41.289 | R2 = 0.9997 | 10–250 | 2.5830 | 0.1024 | | Lung | y = 7.384x + 18.317 | R2 = 0.9997 | 2–50 | 2.0984 | 0.0751 | | Kidney | y = 3.2041x − 2.1837 | R2 = 0.9991 | 10–100 | 3.3257 | 0.0593 | | Stomach | y = 12.132x + 31.51 | R2 = 0.9995 | 2–50 | 4.3045 | 0.1540 | | Uterus | y = 11.729x − 9.8825 | R2 = 0.9990 | 2–50 | 5.8182 | 0.2082 | | Intestine | y = 19.205x − 17.2 | R2 = 0.9992 | 5–500 | 5.4486 | 0.2215 |
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