Tissue Distribution of Total Flavonoids Extracts of Drynariae Rhizoma in Young and Old Rats by UPLC–MS/MS Determination

Table 8

Interday and intraday precision and accuracy data for assays of naringenin in different tissues (n = 6).

Tissues	Spiked (ng/mL)	Interday			Intraday
		Mean ± SD	Precision (RSD, %)	Relative error (RE, %)	Mean ± SD	Precision (RSD, %)	Relative error (RE, %)
Heart	8.10	8.13 ± 1.13	13.90	0.37	8.16 ± 1.08	13.24	0.74
	81.00	82.92 ± 8.68	10.47	2.37	86.88 ± 6.85	7.88	7.26
	162.00	160.32 ± 22.94	14.31	−1.04	167.09 ± 24.86	14.88	3.14
Liver	8.10	8.63 ± 1.20	13.90	6.54	9.09 ± 1.24	13.64	12.22
	405.00	427.60 ± 51.68	12.09	5.58	453.02 ± 42.58	9.40	11.86
	810.00	775.22 ± 90.48	11.67	−4.29	817.22 ± 80.89	9.90	0.89
Spleen	8.10	9.24 ± 1.01	10.93	14.07	9.13 ± 0.93	10.19	12.72
	81.00	85.43 ± 6.78	7.94	5.47	86.86 ± 4.52	5.20	7.23
	162.00	152.55 ± 18.72	12.27	−5.83	151.26 ± 21.45	14.18	−6.63
Lung	8.10	8.81 ± 1.26	14.30	8.77	8.69 ± 0.54	6.21	7.28
	81.00	79.67 ± 9.12	11.45	−1.64	83.38 ± 8.76	10.51	2.94
	162.00	155.57 ± 22.84	14.68	−3.97	151.47 ± 19.85	13.10	−6.50
Kidney	8.10	8.43 ± 1.12	13.29	4.07	8.70 ± 1.21	13.91	7.41
	81.00	82.07 ± 8.79	10.71	1.32	85.59 ± 7.93	9.27	5.67
	162.00	163.46 ± 24.17	14.79	0.90	177.97 ± 10.54	5.92	9.86
Brain	5.05	4.71 ± 0.64	13.59	−6.73	4.76 ± 0.71	14.92	−5.74
	10.10	11.12 ± 1.54	13.85	10.10	11.00 ± 1.54	14.00	8.91
	25.25	26.41 ± 3.44	13.03	4.59	26.19 ± 3.45	13.17	3.72
Stomach	8.10	8.99 ± 1.19	13.24	10.99	8.91 ± 0.81	9.09	10.00
	405.00	412.81 ± 58.73	14.23	1.93	441.06 ± 49.05	11.12	8.90
	810.00	833.38 ± 105.06	12.61	2.89	818.43 ± 80.14	9.79	1.04
Uterus	8.10	8.57 ± 1.13	13.19	5.80	8.96 ± 1.06	11.83	10.62
	81.00	79.55 ± 10.82	13.60	−1.79	80.82 ± 11.94	14.77	−0.22
	162.00	163.07 ± 24.08	14.77	0.66	171.73 ± 24.88	14.49	6.01
Ovary	8.10	8.29 ± 1.08	13.03	2.35	8.66 ± 1.18	13.63	6.91
	81.00	82.27 ± 10.04	12.20	1.57	84.42 ± 12.23	14.49	4.22
	162.00	163.78 ± 23.19	14.16	1.10	164.51 ± 17.65	10.73	1.55
Intestine	8.10	7.63 ± 0.85	11.14	−5.80	7.78 ± 1.05	13.50	−3.95
	405.00	404.43 ± 55.41	13.70	−0.14	428.48 ± 52.94	12.36	5.80
	810.00	770.23 ± 82.03	10.65	−4.91	784.08 ± 102.02	13.01	−3.20