Measurement of Pharmacokinetics and Tissue Distribution of Four Compounds from Nauclea officinalis in Rat Plasma and Tissues through HPLC-MS/MS

Table 6

Summary of primary pharmacokinetic parameters of four analytes (n = 6).

Parameters	Unit	Chlorogenic acid (mean ± SD)	Naucleactonin C (mean ± SD)	Khaephuoside A (mean ± SD)	3,4-dimethoxyphenyl-1-O-β-apiofuroseyl(1 ⟶ 2)-β-D-glucopyranoside (mean ± SD)
AUC (0 − t)	μg/L∗h	482.76 ± 124.95	5281.36 ± 440.02	238.70 ± 46.64	212.99 ± 49.29
AUC (0 − ∞)	μg/L∗h	554.37 ± 166.14	5405.02 ± 416.99	262.16 ± 32.24	440.17 ± 216.99
MRT (0 − t)	h	5.33 ± 0.65	4.76 ± 1.57	3.19 ± 0.24	1.6 ± 0.14
t1/2	h	10.64 ± 6.21	4.59 ± 1.65	3.12 ± 1.70	3.99 ± 2.87
T max	h	0.25 ± 0.00	1.67 ± 0.52	0.29 ± 0.10	0.33 ± 0.13
CL	L/h/kg	62.94 ± 16.00	0.15 ± 0.01	54.40 ± 6.04	28.63 ± 13.64
C max	μg/L	242.42 ± 84.67	1008.58 ± 368.84	106.18 ± 23.30	144.13 ± 35.59
Vz/F	L/kg	915.76 ± 451.75	0.966 ± 0.359	253.289 ± 158.11	127.43 ± 65.93

Abbreviations. AUC, area under the plasma concentration–time curve; MRT, mean residence time; t1/2, elimination half-life; T_max, time to Cmax; CL, clearance rate; C_max, maximum plasma concentration; Vz/F, apparent distribution volume.