Development and Validation of a Liquid Chromatography-Mass Spectrometry Assay for Determination of Cromolyn Sodium in Skin Permeation Studies

Figure 3

Chromatogram showing (a) pure 0.1 μg/mL CS in methanol ((b)-(e)) skin extracts and matrices in methanol based on the blank in vitro permeation study set up with TIC1 = m/x 467 and TIC2 = m/z 379 ((b) and (c)) tape 1 and tapes 16–20 representing the stratum corneum; (d) viable epidermis extract; (e) dermis extract. Abbreviations: CS: cromolyn sodium; TIC, total ion chromatogram.

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