Simultaneous Determination of 32 Pyrrolizidine Alkaloids in Two Traditional Chinese Medicine Preparations by UPLC-MS/MS

Table 3

LODs and LOQs of PAs in various matrices.

Compound	XYT		Extract 1	Extract 2	Atractylodis Macrocephalae Rhizoma	Paeoniae Radix Alba	Bupleuri Radix	Angelicae Sinensis Radix	Glycyrrhizae Radix Et Rhizoma Praeparata Cum Melle
	LOD1 (μg/kg)	LOQ2 (μg/kg)	LOQ (μg/kg)	LOQ (μg/kg)	LOQ (μg/kg)	LOQ (μg/kg)	LOQ (μg/kg)	LOQ (μg/kg)	LOQ (μg/kg)
Em	0.2	0.6	0.4	0.4	0.6	0.7	0.7	0.7	0.6
Er	0.3	1.5	1.2	1.3	1.7	1.7	1.8	1.3	1.1
Eu	0.2	0.5	0.4	0.5	0.2	0.2	0.7	0.2	0.2
He	0.1	0.5	0.2	0.3	0.3	0.4	0.7	0.5	0.4
Ic	0.2	0.6	0.6	0.5	0.3	0.3	0.7	0.7	0.5
Im	0.2	0.7	0.2	0.5	0.2	0.3	0.8	0.5	0.4
Jb	0.2	1.2	1.5	1.4	0.9	1.0	1.9	0.7	1.0
Lc	0.1	0.6	0.2	0.2	0.4	0.2	0.7	0.5	0.4
Ly	0.1	0.5	0.3	0.3	0.4	0.3	0.6	0.2	0.3
Mc	0.3	1.1	0.9	0.7	1.1	1.3	1.7	0.5	1.1
Re	1.2	3.2	2.0	1.8	3.0	2.2	3.5	2.1	2.3
Sk	0.6	1.5	1.3	1.7	1.5	0.9	1.8	1.9	1.2
Sn	0.7	2.4	1.7	1.7	3.2	3.3	3.5	2.7	2.1
Sp	0.4	1.7	0.9	0.8	1.2	2.0	2.0	1.1	1.3
Sv	1.0	3.4	1.7	2.2	3.7	3.0	3.4	2.4	2.1
Td	0.3	1.8	1.6	1.2	1.8	1.2	1.5	1.1	1.1
7-Ly	0.1	0.6	0.3	0.3	0.4	0.3	0.7	0.4	0.3
7-Im	0.1	0.3	0.4	0.5	0.5	0.4	0.6	0.2	0.2
EmNO	1.0	3.7	2.2	2.8	3.0	2.7	3.1	3.4	2.7
ErNO	0.7	1.9	1.8	0.9	1.2	1.2	1.7	0.8	1.0
EuNO	0.5	1.7	1.7	1.2	0.7	1.5	1.2	1.5	1.2
HeNO	0.3	1.4	1.7	1.3	1.5	2.0	1.8	1.8	1.2
IcNO	0.2	0.7	0.7	0.6	0.4	0.5	0.6	0.2	0.4
ImNO	0.2	0.5	0.4	0.6	0.3	0.3	0.5	0.3	0.4
JbNO	0.4	1.6	1.5	1.6	0.9	1.8	1.5	1.2	0.7
LcNO	0.1	0.8	0.4	0.4	0.5	0.3	0.6	0.3	0.3
LyNO	0.3	1.7	1.1	1.4	0.7	1.1	1.5	1.5	0.9
McNO	0.4	1.5	1.7	1.1	1.4	1.5	1.3	0.8	1.0
ReNO	1.7	6.4	4.4	5.6	3.3	6.8	6.8	5.5	7.2
SnNO	0.9	3.2	3.6	2.5	2.6	1.9	3.3	2.6	1.9
SpNO	0.4	1.9	1.8	1.8	1.1	0.9	1.6	1.3	1.1
SvNO	0.8	2.9	3.2	1.9	2.4	3.2	2.0	2.7	3.5

¹ LOD: limit of detection. ² LOQ: limit of quantification.