Chemometric Methods for Simultaneous Determination of Candesartan Cilexetil and Hydrochlorothiazide in Binary Combinations

Table 13

Effect of interferences on the H-point standard addition method.

λ	Regression equation	R^2	Type of interferences	Amount of interferences (µg/mL)	HCT (µg/mL)			CAN (µg/mL)
					Add	Found	%E	Add	Found		%E
283	Y = 0.01202X + 0.5936	0.9946	Polyethylene glycol	100	15	14.98	0.15	15		15.08	0.51
239	Y = 0.03424X + 0.9286	0.9901
283	Y = 0.01219X + 0.6102	0.9923	Sucrose	100	15	15.6	4.07	15		14.8	−1.35
239	Y = 0.03424X + 0.9365	0.9901
283	Y = 0.01155X + 0.6039	0.9902	Lactose	100	15	15.5	3.4	15		15.3	2
239	Y = 0.03353X + 0.9402	0.9938
283	Y = 0.01165X + 0.5931	0.9965	Starch	100	15	14.96	0.29	15		15.6	3.74
239	Y = 0.03449X + 0.9485	0.9995
283	Y = 0.01115X + 0.5776	0.9974	NaHCO3	100	15	14.95	0.34	15		14.89	−0.74
239	Y = 0.03320X + 0.9059	0.9993
283	Y = 0.01197X + 0.6095	0.9967	All of above	100	15	15.5	3.4	15		15.23	1.54
239	Y = 0.03407X + 0.9461	0.9996

¹ calculated using the regression equation of Y = 0.0247x + 0.0297 and the HCT calibration curve at 283 nm.