Chemometric Methods for Simultaneous Determination of Candesartan Cilexetil and Hydrochlorothiazide in Binary Combinations

Table 15

Effect of interferences on the correction absorbance method.

λ	Type of interferences	Amount of interferences (µg/mL)	HCT (µg/mL)			CAN (µg/mL)
			Add	Found	%E	Add	Found	%E
340	Polyethylene glycol	100	15	15.53	3.5	15	15.34	2.5
250
340	Sucrose	100	15	15.24	1.6	15	15.2	1.3
250
340	Lactose	100	15	14.4	−4	15	14.62	−2.5
250
340	Starch	100	15	15.18	1.2	15	15.13	0.92
250
340	NaHCO3	100	15	14.62	−2.5	15	15.34	2.3
250
340	All of above	100	15	15.47	3.1	15	15.11	0.74
250

¹ calculated using the regression equation of Y = 0.0054x + 0.0067 and the HCT calibration curve at 340 nm. ² calculated using the regression equation of Y = 0.0295x + 0.0648 and the HCT calibration curve at 250 nm.