Chemometric Methods for Simultaneous Determination of Candesartan Cilexetil and Hydrochlorothiazide in Binary Combinations

Table 7

Accuracy of the H-point standard addition method in the determination of HCT and CAN.

λ	Regression equation	R^2	Hydrochlorothiazide (HCT)^1 (µg/mL)			Candesartan cilexetil (CAN) (µg/mL)
			Add	Found	%E	Add	Found	%E
283	Y = 0.01141X + 0.5420	0.9917	15	15.3	1.7	11	10.7	2.9
239	Y = 0.03298X + 0.7723	0.9961
283	Y = 0.01147X + 0.5494	0.9911	15	14.6	2.8	13	12.9	0.7
239	Y = 0.03315X + 0.8294	0.9955
283	Y = 0.01141X + 0.5917	0.9917	15	15.4	2.5	15	14.7	1.8
239	Y = 0.03309X + 0.9109	0.9957
283	Y = 0.01154X + 0.6523	0.9903	17	16.97	0.18	15	15.45	3
239	Y = 0.03327X + 0.9882	0.9950
283	Y = 0.01155X + 0.6745	0.9902	19	19.1	0.5	15	15.14	0.9
239	Y = 0.03312X + 1.001	0.9956

¹ calculated using the regression equation of Y = 0.0247x + 0.0297, and the HCT calibration curve at 283 nm.