Environmental Sample Stability for Pharmaceutical Compound Analysis: Handling and Preservation Recommendations

Table 1

Recovery of extraction (RE, %) of the target compounds obtained during the repeatability (intraday precision) test. Average of three replicate SPE extractions of a spiked artificial seawater sample.

Target compounds	5 mg·L^−1		7.5 mg·L^−1		10 mg·L^−1
	RE (%)	RSD (%)	RE (%)	RSD (%)	RE (%)	RSD (%)
ACM	84.2 ± 3.0	3.7	88.2 ± 3.5	3.9	85.3 ± 0.9	1.0
TMP	95.5 ± 3.3	3.4	94.4 ± 0.9	1.0	98.8 ± 0.4	0.4
OTC	88 ± 1.5	1.7	89.3 ± 2.7	3.0	87.8 ± 1.1	1.3
SMX	97.1 ± 1.1	1.1	96.3 ± 2.1	2.1	97.1 ± 0.8	0.9
EE2	81.8 ± 2.1	2.6	85.9 ± 3.9	4.6	80.1 ± 3.2	4.0