A LC-MS/MS Method for Quantifying the Schisandrin B and Exploring Its Intracellular Exposure Correlating Antitumor Effect

Figure 6

Time and spatial variation of Sch.B exposure in nucleus, mitochondria, and cells at 12, 24, 36, and 48 h. A parallel experiment was carried out to measure the cell number and normalize the concentration of Sch.B in single cell (n = 3). (a) The concentration-time curve of Sch.B in the nucleus of HCT116 cells. (b) The concentration-time curve of Sch.B in the mitochondria of HCT116 cells. (c) The concentration-time curve of Sch.B in the HCT116 cells. (d) The comparative results of concentrations of Sch.B in HCT116 cells.

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