Knockout of Vasohibin-1 Gene in Mice Results in Healthy Longevity with Reduced Expression of Insulin Receptor, Insulin Receptor Substrate 1, and Insulin Receptor Substrate 2 in Their White Adipose Tissue

Figure 6

No outbreak of diabetes in vash1^−/− mice. (a) WT and vash1^−/− young male mice were fed a HFD, and body weight and fasting blood glucose were compared. Open circle, WT mice; closed circle, vash1^−/− mice. Means ± SDs are shown (). The statistical significance of differences was calculated by use of the unpaired Student’s -test, and a value of was the criterion for significance. (b) After a 12-week HFD feeding, the GTT was performed. Open circle, WT mice; closed circle, vash1^−/− mice. Area under the curve (AUC) is shown on the right. Means ± SDs are given (). The statistical significance of differences was calculated by performing the unpaired Student’s -test, and a value of was the criterion for significance. (c) After a 12-week HFD feeding, the ITT was performed. Open circle, WT mice; closed circle, vash1^−/− mice. AUC is shown on the right. Means ± SDs are given (). The statistical significance of differences was calculated by use of the unpaired Student’s -test, and a value of was taken as the criterion for significance. .

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