Knockout of Vasohibin-1 Gene in Mice Results in Healthy Longevity with Reduced Expression of Insulin Receptor, Insulin Receptor Substrate 1, and Insulin Receptor Substrate 2 in Their White Adipose Tissue

Table 1

Biochemical analysis of sera from WT and vash1^−/− mice.

	WT ()	Vash1^−/− ()	value
TP (g/dL)			0.6795
ALB (g/dL)			0.9900
BUN (mg/dL)			0.7779
CRE (mg/dL)			0.0164
Na (mEq/L)			0.3896
K (mEq/L)			0.6998
Cl (mEq/L)			0.1144
Ca (mg/dL)			0.0584
IP (mg/dL)			0.7440
Fe (mg/dL)			0.0842
AST (IU/L)			0.4317
ALT (IU/L)			0.2497
ALP (IU/L)			0.9168
LDH (IU/L)			0.8494
LAP (IU/L)			0.2590
AMY (IU/L)			0.5394
CK (IU/L)			0.7544
ChE (IU/L)			0.2773
Lip (IU/L)			0.1844
T-CHOL (mg/dL)			0.0379
F-CHOL (mg/dL)			0.0464
E-CHOL (mg/dL)			0.0373
TG (mg/dL)			0.0594
PL (mg/dL)			0.0328
NEFA (mEq/L)			0.8519
LDL-C (mg/dL)			0.0689
HDL-C (mg/dL)			0.0968
T-BIL (mg/dL)			0.0114
D-BIL (mg/dL)			0.0311
I-BIL (mg/dL)			0.0631
TBA (mmol/L)			0.1626
TL (mg/dL)			0.2126
GLU (mg/dL)			0.6310
PA (mg/dL)			0.2482
LA (mg/dL)			0.4124
T-KB (mmol/L)			0.6232

Total protein (TP), albumin (ALB), blood urea nitrogen (BUN), creatinine (CRE), uric acid (UA), sodium (Na), potassium (K), chloride (Cl), calcium (Ca), inorganic phosphorous (IP), iron (Fe), aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), leucine aminopeptidase (LAP), amylase (AMY), creatine kinase (CK), choline esterase (ChE), lipase (Lip), total cholesterol (T-CHOL), free cholesterol (F-CHOL), esterified cholesterol (E-CHOL), triglyceride (TG), phospholipid (PL), nonesterified fatty acid (NEFA), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total bilirubin (T-BIL), direct bilirubin (D-BIL), indirect bilirubin (I-BIL), total bile acid (TBA), total lipid (TL), blood glucose (GLU), pyruvic acid (PA), lactic acid (LA), and total ketone body (T-KB). Means ± SDs and values are shown.