Research Article
Evaluation of Potential Drug-Drug Interactions with Medications Prescribed to Geriatric Patients in a Tertiary Care Hospital
Table 6
Medication pairs involved in risk X category drug interactions (to be avoided).
| | Medication pairs | Number of D/Is | Effect of drug interaction |
| | Azithromycin-silodosin | 1 | Increased serum concentration of silodosin | | Domperidone-escitalopram | 2 | Enhanced QTc-prolonging effect | | Domperidone-quetiapine | 2 | Enhanced QTc-prolonging effect | | Escitalopram-quetiapine | 1 | Enhanced QTc-prolonging effect | | Atorvastatin-silodosin | 2 | Increased serum concentration of silodosin | | Clopidogrel-esomeprazole | 4 | Diminished antiplatelet effect of clopidogrel | | Ciprofloxacin-domperidone | 1 | Enhanced QTc-prolonging effect | | Domperidone-fluconazole | 1 | Increased serum concentration of domperidone | | Nifedipine-phenytoin | 1 | Increased serum concentration of phenytoin | | Prazosin-tamsulosin | 1 | Enhanced antihypertensive effect | | Domperidone-granisetron | 1 | Enhanced QTc-prolonging effect | | Escitalopram-flupentixol | 1 | Enhanced QTc-prolonging effect | | Bambuterol-salmeterol | 1 | Enhanced adverse/toxic effects | | Amitriptyline-salbutamol + ipratropium | 1 | Enhanced anticholinergic effect |
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