Association of Race and Major Adverse Cardiac Events (MACE): The Atherosclerosis Risk in Communities (ARIC) Cohort

Table 3

Association between race and major adverse cardiac events (MACE), adjusting for traditional risk factors for MACE and SNPs; results of Cox proportional hazard models with all participants and with data from only unrelated participants^c; ARIC, 1987–1989.

All participants	N	HR (95% CI)	Variable (s) in model
Model 1	12770	1.46 (1.32,1.61)^a	Race
Model 2	12751	1.55 (1.40,1.72)^a	Model 1 + age, gender, and BMI
Model 3	12704	1.32 (1.18,1.47)^a	Model 2 + alcohol use and cigarette use
Model 4	12512	1.19 (1.06,1.33)^b	Model 3 + marital status and educational status
Model 5	12409	1.24 (1.10,1.39)^a	Model 4 + current aspirin use
Model 6	12189	0.98 (0.87,1.11)	Model 5 + high cholesterol, diabetes, and hypertension
Only unrelated
Participants	N	HR (95% CI)	Variable (s) in model
Model 1	11843	1.42 (1.31,1.54)^a	Race
Model 2	11825	1.55 (1.43,1.69)^a	Model 1 + age, gender, and BMI
Model 3	11781	1.33 (1.22,1.45)^a	Model 2 + alcohol use and cigarette use
Model 4	11601	1.19 (1.08,1.30)^b	Model 3 + marital status and educational status
Model 5	11505	1.22 (1.11,1.34)^a	Model 4 + current aspirin use
Model 6	11299	1.04 (0.95,1.6)	Model 5 + high cholesterol, diabetes, and hypertension

Reference is the white race; ; ; ^cin cases of familial relatedness, only data from the first enrolled individual were used.