Genetic and Epigenetic Tumor Suppressor Gene Silencing Are Distinct Molecular Phenotypes Driven by Growth Promoting Mutations in Nonsmall Cell Lung Cancer

Table 2

Item response model for NSCLC promoter hypermethylation and covariates.

	Est	SE	P
Item response intercepts
DAPK	−1.10	0.22	<.0001
RASSF1A	−0.20	0.17	.24
CDKN2A	−0.84	0.18	<.0001
MGMT	−0.66	0.27	.02
RARB	0.82	0.28	.004
SFRP1	2.24	0.42	<.0001
SFRP2	2.80	0.51	<.0001
SFRP4	−0.86	0.28	.002
SFRP5	1.67	0.42	.0001
CDH1	0.88	0.36	.01
APC	−1.83	0.25	<.0001
PYCARD	−2.99	0.42	<.0001
LAMAC2	−0.38	0.40	.35
CDH13	0.03	0.24	.90
MLH1	−3.77	0.57	<.0001
CCND2	−0.90	0.32	.006
PRSS3	0.20	0.19	.30
Item response slopes
DAPK	0.50	0.24	.04
RASSF1	−0.16	0.17	.33
CDKN2A	0.11	0.19	.56
MGMT	1.02	0.26	.0001
RARB	0.98	0.24	<.0001
SFRP1	1.70	0.29	<.0001
SFRP2	1.68	0.35	<.0001
SFRP4	0.99	0.26	.0002
SFRP5	1.67	0.27	<.0001
CDH1	1.43	0.28	<.0001
APC	0.15	0.22	.50
PYCARD	0.61	0.25	.01
LAMAC2	1.82	0.27	<.0001
CDH13	0.84	0.24	.0005
MLH1	0.14	0.40	.72
CCND2	1.32	0.28	<.0001
PRSS3	0.43	0.19	.02
Latent trait mean effects
Gender
Male	Referent
Female	−0.34	0.22	.11
KRAS codon 12 mutation
No mutation	Referent
Mutation	0.54	0.28	.05
3p21 LOH FAL score
0–0.3	Referent
>0.3	−0.56	0.24	.02