Assessing Candidate Gene nsSNPs for Phenotypic Differences in Double-Strand Break Repair Using Radiation-Induced 𝛾H2A.X Foci

Figure 2

Preliminary dose- and time-response patterns based on control cell line GM12154 for the mean number of γH2A.X foci following gamma irradiation. Two independent experiments, each containing two replicates (~200 cells each), were used for the analyses. (a) Linear dose response at 0.5 hour following gamma irradiation (R²  =  0.99). Error bars represent ±1 SEM for two experiments. (b) Non-linear time response to 1.5 Gy gamma irradiation. The time point, NT, represents preexposure cells. Error bars represent ±1 SEM for two experiments.

(a)

(b)