Assessing Candidate Gene nsSNPs for Phenotypic Differences in Double-Strand Break Repair Using Radiation-Induced 𝛾H2A.X Foci

Table 3

Comparison of the number of foci at various time points (T0, before irradiation; T1, T3, T24, respectively, 1 hour, 3 hours, 24 hours, following irradiation.)

Gene	nsSNP	Ratios of geometric means^†
		T1/T0	T3/T1	T24/T0
PNKP	rs3739186	4.65	0.67	1.25
BRCA1	rs1799950	4.51	0.65	1.09
LIG4	rs1805388	3.94	0.64	1.08
WRN	rs1346044	3.83	0.64	1.11
ATM	rs1800057	4.20	0.62	1.31
CONTROLS		4.10	0.64	1.16

^†None of the ratios for any cell line panel representing SNPs was statistically significantly different from the corresponding ratio for controls. (𝑃>.05, t-tests comparing coefficients from a mixed model regression fitted separately to the base-2 logarithm of each ratio).