Journal of Cancer Epidemiology / 2012 / Article / Tab 2 / Research Article
Cardiovascular Events in Cancer Patients Treated with Highly or Moderately Emetogenic Chemotherapy: Results from a Population-Based Study Table 2 Cardiovascular-related events in 5827 patients with select* cancers and ≤4 cycles of HEC, MEC, or HEC/MEC combined, 2005–2007 IMPACT National Benchmark Database (OptumInsight, Eden Prairie, MN).
Cardiovascular and thromboembolic events HEC and/or MEC HEC only MEC only HEC plus MEC
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% Angina pectoris 32 0.55 3 0.91 28 0.53 1 0.44 Arterial disorder 9 0.15 2 0.61 7 0.13 0 — Arterial occlusive disease 2 0.03 0 — 2 0.04 0 — Arterial thromboembolic (excluding chest pain/discomfort) 254 4.36 23 6.97 220 4.18 11 4.82 Arterial thromboembolic (including chest pain/discomfort) 881 15.12 72 21.82 754 14.31 55 24.12 Cardiac arrest 25 0.43 4 1.21 19 0.36 2 0.88 Cardiac disorder 3 0.05 0 — 3 0.06 0 — Cardio-respiratory arrest 27 0.46 4 1.21 21 0.40 2 0.88 Cardiogenic shock 1 0.02 0 — 1 0.02 0 — Cerebral ischemia 62 1.06 8 2.42 53 1.01 1 0.44 Cerebrovascular accident 52 0.89 3 0.91 49 0.93 0 — Chest pain or discomfort 719 12.34 62 18.79 610 11.58 47 20.61 Circulatory collapse 14 0.24 1 0.30 13 0.25 0 — Embolism 97 1.66 8 2.42 83 1.58 6 2.63 Hypertension 966 16.58 68 20.61 854 16.21 44 19.30 Hypotension 149 2.56 11 3.33 126 2.39 12 5.26 Iliac artery embolism 2 0.03 1 0.30 1 0.02 0 — Increased platelets 7 0.12 0 — 7 0.13 0 — Intermittent claudication 9 0.15 2 0.61 4 0.08 3 1.32 Myocardial infarction 11 0.19 1 0.30 10 0.19 0 — Myocardial ischemia 11 0.19 0 — 11 0.21 0 — Peripheral embolism 38 0.65 4 1.21 30 0.57 4 1.75 Peripheral ischemia — — 0 — 0 — 0 — Sudden death — — 0 — 0 — 0 — Syncope 140 2.40 12 3.64 117 2.22 11 4.82 Venous thromboembolic 450 7.72 40 12.12 383 7.27 27 11.84
*
Breast, colorectal, head and neck, lung, and ovarian cancers.
