Research Article

Cardiovascular Events in Cancer Patients Treated with Highly or Moderately Emetogenic Chemotherapy: Results from a Population-Based Study

Table 3

Cardiovascular-related events in 5827 patients with select* cancers and ≤4 cycles of HEC, MEC, or HEC/MEC combined, by aprepitant status, 2005–2007 IMPACT National Benchmark Database (OptumInsight, Eden Prairie, MN).

Cardiovascular and thromboembolic eventsHEC and/or MECHEC onlyMEC onlyHEC/MEC combined
No AprepAprepNo AprepAprepNo AprepAprepNo AprepAprep
( 𝑁 = 2 0 1 0 ) ( 𝑁 = 3 8 1 7 ) ( 𝑁 = 1 6 5 ) ( 𝑁 = 1 6 5 ) ( 𝑁 = 1 7 5 6 ) ( 𝑁 = 3 5 1 3 ) ( 𝑁 = 8 9 ) ( 𝑁 = 1 3 9 )
𝑛 % 𝑛 % 𝑛 % 𝑛 % 𝑛 % 𝑛 % 𝑛 % 𝑛 %

Angina pectoris200.52120.6021.2110.61180.51100.57011.12
Arterial disorder30.0860.3010.6110.6120.0650.2800
Arterial occlusive disease10.0310.050010.0310.0600
Arterial thromboembolic (excludes chest pain/discomfort)1965.13582.89148.4895.451754.98452.5675.0444.49
Arterial thromboembolic (includes chest pain/discomfort)61116.0127013.434024.243219.3953415.2022012.533726.621820.22
Cardiac arrest220.5830.1521.2121.21180.5110.0621.440
Cardiac disorder20.0510.050020.0610.0600
Cardio-respiratory arrest240.6330.1521.2121.21200.5710.0621.440
Cardiogenic shock10.0300010.03000
Cerebral ischemia501.31120.6042.4242.42451.2880.4610.720
Cerebrovascular accident461.2160.3031.820431.2260.3400
Chest pain or discomfort48812.7823111.493621.822615.7642011.9619010.823223.021516.85
Circulatory collapse110.2930.1510.610100.2830.1700
Embolism772.02201.0053.0331.82681.94150.8542.8822.25
Hypertension69718.2626913.384124.852716.3662917.9022512.812719.421719.10
Hypotension1173.07321.5974.2442.421042.96221.2564.3266.74
Iliac artery embolism10.0310.05010.6110.03000
Increased platelets60.1610.050060.1710.0600
Intermittent claudication50.1340.2010.6110.6130.0910.0610.7222.25
Myocardial infarction110.29010.610100.28000
Myocardial ischemia90.2420.100090.2620.1100
Peripheral embolism250.65130.6521.2121.21210.6090.5121.4422.25
Peripheral ischemia00000000
Sudden death00000000
Syncope962.52442.1942.4284.85862.45311.7764.3255.62
Venous thromboembolic3088.071427.062414.55169.702687.631156.551611.511112.36

* Breast, colorectal, head and neck, lung, and ovarian cancers.