Journal of Cancer Epidemiology / 2012 / Article / Tab 3 / Research Article
Cardiovascular Events in Cancer Patients Treated with Highly or Moderately Emetogenic Chemotherapy: Results from a Population-Based Study Table 3 Cardiovascular-related events in 5827 patients with select* cancers and ≤4 cycles of HEC, MEC, or HEC/MEC combined, by aprepitant status, 2005–2007 IMPACT National Benchmark Database (OptumInsight, Eden Prairie, MN).
Cardiovascular and thromboembolic events HEC and/or MEC HEC only MEC only HEC/MEC combined No Aprep Aprep No Aprep Aprep No Aprep Aprep No Aprep Aprep
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% Angina pectoris 20 0.52 12 0.60 2 1.21 1 0.61 18 0.51 10 0.57 0 — 1 1.12 Arterial disorder 3 0.08 6 0.30 1 0.61 1 0.61 2 0.06 5 0.28 0 — 0 — Arterial occlusive disease 1 0.03 1 0.05 0 — 0 — 1 0.03 1 0.06 0 — 0 — Arterial thromboembolic (excludes chest pain/discomfort) 196 5.13 58 2.89 14 8.48 9 5.45 175 4.98 45 2.56 7 5.04 4 4.49 Arterial thromboembolic (includes chest pain/discomfort) 611 16.01 270 13.43 40 24.24 32 19.39 534 15.20 220 12.53 37 26.62 18 20.22 Cardiac arrest 22 0.58 3 0.15 2 1.21 2 1.21 18 0.51 1 0.06 2 1.44 0 — Cardiac disorder 2 0.05 1 0.05 0 — 0 — 2 0.06 1 0.06 0 — 0 — Cardio-respiratory arrest 24 0.63 3 0.15 2 1.21 2 1.21 20 0.57 1 0.06 2 1.44 0 — Cardiogenic shock 1 0.03 0 — 0 — 0 — 1 0.03 0 — 0 — 0 — Cerebral ischemia 50 1.31 12 0.60 4 2.42 4 2.42 45 1.28 8 0.46 1 0.72 0 — Cerebrovascular accident 46 1.21 6 0.30 3 1.82 0 — 43 1.22 6 0.34 0 — 0 — Chest pain or discomfort 488 12.78 231 11.49 36 21.82 26 15.76 420 11.96 190 10.82 32 23.02 15 16.85 Circulatory collapse 11 0.29 3 0.15 1 0.61 0 — 10 0.28 3 0.17 0 — 0 — Embolism 77 2.02 20 1.00 5 3.03 3 1.82 68 1.94 15 0.85 4 2.88 2 2.25 Hypertension 697 18.26 269 13.38 41 24.85 27 16.36 629 17.90 225 12.81 27 19.42 17 19.10 Hypotension 117 3.07 32 1.59 7 4.24 4 2.42 104 2.96 22 1.25 6 4.32 6 6.74 Iliac artery embolism 1 0.03 1 0.05 0 — 1 0.61 1 0.03 0 — 0 — 0 — Increased platelets 6 0.16 1 0.05 0 — 0 — 6 0.17 1 0.06 0 — 0 — Intermittent claudication 5 0.13 4 0.20 1 0.61 1 0.61 3 0.09 1 0.06 1 0.72 2 2.25 Myocardial infarction 11 0.29 0 — 1 0.61 0 — 10 0.28 0 — 0 — 0 — Myocardial ischemia 9 0.24 2 0.10 0 — 0 — 9 0.26 2 0.11 0 — 0 — Peripheral embolism 25 0.65 13 0.65 2 1.21 2 1.21 21 0.60 9 0.51 2 1.44 2 2.25 Peripheral ischemia 0 — 0 — 0 — 0 — 0 — 0 — 0 — 0 — Sudden death 0 — 0 — 0 — 0 — 0 — 0 — 0 — 0 — Syncope 96 2.52 44 2.19 4 2.42 8 4.85 86 2.45 31 1.77 6 4.32 5 5.62 Venous thromboembolic 308 8.07 142 7.06 24 14.55 16 9.70 268 7.63 115 6.55 16 11.51 11 12.36
*
Breast, colorectal, head and neck, lung, and ovarian cancers.
