Impact on Medical Cost, Cumulative Survival, and Cost-Effectiveness of Adding Rituximab to First-Line Chemotherapy for Follicular Lymphoma in Elderly Patients: An Observational Cohort Study Based on SEER-Medicare

Table 2

Multivariate cost analysis—all patients.

	Type of cost
	Total			Immunochemotherapy			Other cancer			Noncancer
	Coef.	95% CI		Coef.	95% CI		Coef.	95% CI		Coef.	95% CI
		Lower	Upper		Lower	Upper		Lower	Upper		Lower	Upper
First-lines therapy
Chemotherapy alone	Reference category
Rituximab plus chemotherapy	$18,695	$9,302	$28,643	$13,336	$9,364	$17,552	$4,816	−$1,899	$11,303	$351	−$3,481	$4,202
Age at diagnosis (years)
66–70	Reference category
71–75	−$1,618	−$12,630	$9,175	−$1,220	−$5,593	$2,925	−$2,270	−$10,015	$5,198	$1,828	−$1,952	$5,472
76–80	−$1,400	−$12,542	$10,379	−$704	−$5,460	$4,345	−$3,617	−$10,665	$3,634	$3,083	−$921	$7,077
>80	−$9,865	−$22,344	$1,980	−$8,374	−$13,699	−$3,221	−$943	−$8,575	$6,986	−$504	−$4,521	$3,435
Gender
Male	Reference category
Female	−$7,732	−$16,027	$19	−$2,628	−$6,155	$730	−$3,64 5	−$9,104	$1,701	−$1,48 9	−$4,739	$1,455
Race/ethnicity
White	Reference category
Black	$7,307	−$26,205	$44,598	$4,496	−$8,111	$20,403	$9,852	−$8,428	$31,109	−$5,999	−$15,809	$406
Hispanic	$15,780	−$6,890	$41,915	−$1,316	−$7,856	$5,837	$16,990	−$502	$36,055	−$53	−$6,339	$6,827
Other	−$29,492	−$45,805	−$13,944	−$15,023	−$20,618	−$8,565	−$6,436	−$17,445	$5,516	−$7,869	−$14,022	−$1,893
Year of diagnosis
1999–2002	Reference category
2003–2005	$4,638	−$4,847	$13,587	$3,148	−$593	$7,091	$534	−$5,996	$6,482	$1,176	−$2,202	$4,629
Stage at FL diagnosis
I & II	Reference category
III & IV	$7,953	−$382	$16,574	$5,955	$2,569	$9,367	$5,363	−$472	$11,028	−$3,280	−$6,676	$210
Histology (grade)
1	Reference category
2	$3,350	−$8,410	$14,992	$1,175	−$3,653	$6,292	−$482	−$9,605	$8,380	$2,659	−$2,156	$7,226
3	−$2,251	−$13,262	$8,903	−$3,576	−$8,221	$909	$519	−$7,512	$9,077	$645	−$3,791	$5,058
4	−$6,155	−$17,656	$3,862	−$4,305	−$8,814	$585	−$3,237	−$10,800	$4,653	$1,452	−$2,697	$5,447
Extranodal involvement
No	Reference category
Yes	$15,429	$6,543	$25,246	$614	−$2,870	$4,076	$12,827	$6,714	$19,419	$2,282	−$924	$5,733
Presence of “B” symptoms
No	Reference category
Yes	$7,901	−$5,056	$19,189	$4,458	−$338	$9,085	$6,628	−$1,689	$15,435	−$2,854	−$6,581	$544
Anemia
No	Reference category
Yes	$9,471	−$16,737	$37,624	$7,299	−$2,203	$18,918	$6,586	−$10,949	$24,028	−$4,184	−$11,569	$3,381
NCI comorbidity index
0	Reference category
1	$9,074	−$325	$18,531	−$205	−$4,134	$3,766	$894	−$4,562	$5,990	$6,320	$2,334	$10,293
2	$21,541	$1,106	$43,054	−$2,419	−$10,259	$6,117	$14,441	$2,063	$27,760	$10,422	$3,978	$17,034
≥3	$51,102	−$4,052	$109,569	−$13,402	−$20,651	−$4,565	$28,545	−$221	$66,725	$35,295	$8,962	$63,847
Performance status indicators
None	Reference category
≥1	$14,290	$176	$28,357	$992	−$3,732	$6,402	$11,482	$3,017	$20,859	$2,030	−$4,216	$8,022
Percent in census tract with some college
<25%	Reference category
≥25%	−$9,060	−$18,039	−$394	−$2,377	−$6,119	$1,049	−$5,302	−$11,598	$756	−$1,591	−$5,376	$1,884
Percent in census tract living in poverty
<5%	Reference category
5–7%	$2,880	−$9,216	$15,965	$2,902	−$3,293	$9,382	−$130	−$8,385	$8,786	$35	−$3,836	$4,240
8–12%	−$287	−$10,343	$10,485	−$897	−$5,483	$3,493	−$841	−$8,040	$6,266	$1,740	−$2,250	$5,883
>12%	−$446	−$10,504	$10,185	−$2,183	−$6,934	$1,760	$216	−$7,196	$7,392	$1,387	−$2,399	$5,359
Type of geographic area
Large metropolitan	Reference category
Metropolitan	−$8,072	−$16,491	$209	−$2,823	−$6,417	$721	−$3,636	−$10,007	$2,971	−$1,660	−$4,971	$1,880
Urban	−$16,680	−$30,663	−$1,544	−$292	−$7,743	$7,925	−$11,881	−$21,215	−$2,092	−$4,485	−$8,889	$199
Less urban/rural	−$13,484	−$23,951	−$2,186	−$3,236	−$8,583	$1,656	−$8,269	−$15,086	−$712	−$2,286	−$7,559	$3,189