Endometrial Tumor Classification by Histomorphology and Biomarkers in the Nurses’ Health Study

Figure 2

Self-organized hierarchical clustering of 12 biomarkers in 274 endometrial cancers. Dendrogram shows degree of marker association (distance measure) in 274 cases with complete data for all markers (cases with partial missing data excluded for computational reasons). Estrogen (ER) and progesterone (PR) receptor results scored dichotomously across a 10% threshold. Two major clusters are evident, containing P53 and PTEN, respectively. Ward’s linkage method and Jaccard similarity coefficient distance metric for binary data. Distal branches, such as those containing and , indicate a level of association between members of the limb.