Endometrial Tumor Classification by Histomorphology and Biomarkers in the Nurses’ Health Study

Table 1

Biomarker scoring and rationale for inclusion.

Marker	Rationale	#scoring
AMACAR	Candidate clear cell type marker	(neg), ,
ARID1A	Candidate clear cell type marker	(pos), (neg),
Hnf1beta	Candidate clear cell type marker	(neg), ,
Napsin A	Candidate clear cell type marker	(neg), ,
p16	Candidate serous type marker	(neg or patchy), ,
ER	Hormone responsiveness	Percentage positive nuclear staining: (<10% staining), (≥10% staining); also
PR	Hormone responsiveness	Percentage positive nuclear staining: (<10% staining), (≥10% staining)
PAX8	Müllerian (paramesonephric) lineage marker	, ,
PAX2	Primary inactivation mechanism	(pos), (neg),
p53	Primary mutation mechanism	, , strong (mutated) expression
PTEN	Primary mutation mechanism	(pos), (neg),
GATA3	Wolffian (mesonephric) lineage marker	(neg), ,

^#WT = wild type; NI = not informative; pos = positive; neg = negative.