Antiadhesive Property of Photoreactive Azidophenyl Low-Molecular-Weight Chitosan in Rabbit Laminotomy Model
Figure 5
Histological sections (H&E staining, 1.25) and magnified views (40, dotted boxes) at weeks 6 and 12 after the operation ((a) control, group I; (b) HA-CMC, group II; (c) P-ALMC, group III). Group I at both 6 and 12 weeks showed entire scar tissue adhesion to the entire exposed dura (D), graded 4. Group II showed a nondistorted dural contour, but the extent of adhesion (adhesion (dotted line)/laminotomy defect (solid line)) was graded 2 at week 6 and graded 0 at week 12. Group III showed a maintained clear area (asterisks) from the dura to the scar tissue at weeks 6 and 12, graded 0.
