Synthesis and Biological Evaluation of New N,N′-Bis(1-substituted-ethylidene)-ethane1,2-diamine and Their Acetyl and Trifluoroacetyl Derivatives as Cytotoxic and Antimicrobial Agents

Table 5

Antibacterial and antifungal data of Schiff bases and their acyl derivatives 2–5.

Compound	Zone of inhibition in mm
	Escherichia coli	Staphylococcus aureus	Aspergillus niger	Candida albicans
2a	12	14	13	12
2b	17	17	15	15
2c	15	15	14	16
2d	14	16	13	15
2e	15	17	16	14
2f	16	15	14	15
2g	18	16	15	14
2h	19	18	18	17
2i	13	15	14	12
2j	15	14	16	11
2k	16	13	14	10
3a	24	25	26	25
3b	31	29	28	29
3c	27	26	26	26
3d	28	27	28	25
3e	27	25	26	27
3f	30	28	29	28
3g	27	26	25	24
3h	29	27	26	25
3i	28	24	25	26
4a	19	16	20	18
4b	22	20	21	20
4c	17	16	15	16
5a	26	25	24	22
5b	27	24	25	21
Ampicillin	32	28	—	—
Griseofulvin	—	—	31	29