Research Article
: A Mild, Efficient, and Reusable Catalyst for the One-Pot Synthesis of 1,2,4,5-Tetra Substituted Imidazoles
Table 1
Solvent effect for the synthesis of (5-a).
| | Entry | Solvent | Time (min) | Temperature (°C) | Catalyst (mol %) | Yield (%) |
| | 1 | CH3CN | 180 | Reflux | (0.2) | 30 | | 2 | AcOH | 180 | Reflux | (0.2) | 30 | | 3 | EtOH | 180 | Reflux | (0.2) | 40 | | 4 | — | 90 | 140 | (0.2) | 92 |
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