Synthesis and Bioevaluation of Thieno[2,3-d]pyrimidinone Derivatives as Potential Tumor Cell Growth Inhibitors

Table 1

The chemical structure of salicylamide derivatives 6a–i.

Entry	Compd. no.	Substituents		Appearance	Mp (°C)	Yield (%)^a
		𝑛	G
1	6a	1		White powder	159.2–160.0	75
2	6b	2		Yellowish solid	111.6–112.0	80
3	6c	3		Colorless crystal	140.5–141.6	72
4	6d	1		White powder	122.6–124.2	58
5	6e	2		Colorless needle crystal	133.2–136.8	78
6	6f	3		Colorless crystal	112.6–114.2	74
7	6g	1		Yellowish solid	105.3–106.5	54
8	6h	2		Colorless needle crystal	104.2–105.0	92
9	6i	3		Colorless needle crystal	145.7–147.1	68

aIsolated yield.