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Journal of Chemistry
/
2013
/
Article
/
Tab 1
/
Research Article
Development and Validation of Stability Indicating HPTLC and HPLC Methods for Simultaneous Determination of Telmisartan and Atorvastatin in Their Formulations
Table 1
Data for calibration graphs and system suitability (
).
Parameter
RP-LC
HPTLC
TLM
ATV
TLM
ATV
Linearity range
12–72 µg/mL
3–18 µg/mL
40–240 ng/band
10–60 ng/band
Regression equation
Slope
1.1134
1.1376
0.9702
0.8021
Intercept
0.9871
1.0950
1.1000
1.4422
Correlation coefficient (
)
0.9999
0.9992
0.9998
0.9994
Limit of detection (LOD)
3.21 µg/mL
1.21 µg/mL
8.02 ng/band
2.13 ng/band
Limit of quantification (LOQ)
8.65 µg/mL
2.25 µg/mL
26.72 ng/band
6.22 ng/band
System suitability
Asymmetry
1.47
1.13
Number of theoretical plates
8641
3721
Capacity factor
5.67
9.73
Resolution
3.158
—
Tailing factor
0.35
0.22
TLM: Telmisartan; ATV: Atorvastatin.