Research Article

Development and Validation of Stability Indicating HPTLC and HPLC Methods for Simultaneous Determination of Telmisartan and Atorvastatin in Their Formulations

Table 1

Data for calibration graphs and system suitability ( ).

ParameterRP-LCHPTLC
TLMATVTLMATV

Linearity range 12–72 µg/mL3–18 µg/mL40–240 ng/band10–60 ng/band
Regression equation
Slope1.11341.13760.97020.8021
Intercept0.98711.09501.10001.4422
Correlation coefficient ( )0.99990.99920.99980.9994
Limit of detection (LOD)3.21 µg/mL1.21 µg/mL8.02 ng/band2.13 ng/band
Limit of quantification (LOQ)8.65 µg/mL2.25 µg/mL26.72 ng/band6.22 ng/band

System suitability
Asymmetry1.471.13
Number of theoretical plates86413721
Capacity factor 5.679.73
Resolution 3.158
Tailing factor0.350.22

TLM: Telmisartan; ATV: Atorvastatin.