Synthesis and Evaluation of New Phthalazine Urea and Thiourea Derivatives as Carbonic Anhydrase Inhibitors

Table 1

IC₅₀ (μM) values of the phthalazine substituted urea and thiourea derivatives.

	hCA I	hCA II		hCA I	hCA II
1	12,08	11,89	3h	14,04	17,78
2	10,18	10,25	3i	6,76	6,75
3a	6,40	6,13	3j	20,38	22,73
3b	13,97	15,35	3k	16,38	16,34
3c	18,20	23,63	3l	12,62	12,34
3d	19,59	18,21	3m	7,63	9,67
3e	11,02	8,50	3n	8,20	8,74
3f	12,20	19,12	3o	7,45	10,03
3g	8,72	8,25	3p	11,72	10,04