Synthesis of Novel 1,2,4-Triazole Derivatives as Antimicrobial Agents via the Japp-Klingemann Reaction: Investigation of Antimicrobial Activities

Table 1

Characterization data of synthesized compounds.

Comp.	Melting point (°C)	Solvent of crystallization	Yield (%)	Formula; (Molecular mass)	Analysis calcd./found
					C	H	N
2a	130-131	Methanol	60	C27H25N7O2; (479)	67.63; 67.62	5.25; 5.23	20.45; 20.46
2b	140-141	Methanol	62	C27H24ClN7O2; (513)	63.09; 63.07	4.71; 4.72	19.08; 19.05
2c	131-132	Methanol	63	C27H24ClN7O2; (513)	63.09; 63.08	4.71; 4.73	19.08; 19.04
2d	123-124	Ethanol	60	C27H24ClN7O2; (513)	63.09; 63.04	4.71; 4.72	19.08; 19.05
2e	127-128	Methanol	62	C28H27N7O2; (493)	68.14; 68.12	5.51; 5.53	19.4; 19.2
2f	130-131	Ethanol	66	C27H25N7O3; (495)	65.44	5.09	19.79
2g	119–121	Ethanol	70	C28H27N7O3; (509)	65.43; 66.03	5.06; 5.35	19.78; 19.23
3a	141-142	Ethanol	71	C32H30N8O4; (590)	65.07; 65.08	5.12; 5.13	18.97; 18.96
3b	118–120	Ethanol	66	C32H29ClN8O4; (624)	61.49; 61.50	4.68; 4.69	17.93; 17.90
3c	134-135	Ethanol	60	C32H29ClN8O4; (624)	61.49; 61.51	4.68; 4.68	17.93; 17.92
3d	125-126	Ethanol	60	C32H29ClN8O4; (624)	61.49; 61.49	4.68; 4.67	17.93; 17.89
3e	112–114	Ethanol	65	C33H32N8O4; (604)	65.55; 65.53	5.33; 5.35	18.53; 18.50
3f	128-129	Ethanol	69	C32H30N8O5; (606)	52.36; 52.33	4.4; 4.1	18.47; 18.49
3g	115-116	Ethanol	71	C33H32N8O5; (620)	63.3; 63.4	5.20; 5.21	18.05; 18.04
4a	158–160	Ethanol	52	C32H32N10O2; (586)	65.29; 65.28	5.48; 5.49	23.79; 23.78
4b	145-146	Ethanol	57	C32H31ClN10O2; (622)	61.68; 61.65	5.01; 5.02	22.48; 22.47
4c	121-122	Ethanol	68	C32H31ClN10O2; (622)	61.68; 61.65	5.01; 5.02	22.48; 22.47
4d	143-144	Ethanol	64	C32H31ClN10O2; (622)	61.68; 61.65	5.01; 5.02	22.48; 22.47
4e	130–132	Ethanol	70	C33H34N10O2; (602)	65.76; 65.75	5.69; 5.68	23.24; 23.27
4f	149–151	Ethanol	72	C32H32N10O3; (604)	63.56; 63.57	5.33; 5.34	23.16; 23.14
4g	128-129	Ethanol	68	C33H34N10O3; (618)	64.06; 64.04	5.54; 5.55	22.64; 22.65